@article {469, title = {Oral Glucose Tolerance Activity of Bawang Dayak (Eleutherine palmifolia L. Merr.) Bulbs Extract Based on the Use of different Extraction Method}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {49-54}, type = {Original Article}, chapter = {49}, abstract = {

Background: Bulbs of Bawang Dayak (Eleutherine palmifolia L. Merr; Synonym: Eleutherine americana L. Merr) from family Iridaceae is widely found and grown in Kalimantan island. The local tribe \“Dayak\” commonly consume this plant and become a traded commodity in traditional markets. This plant is trusted to treat various diseases. Objective: The present study aims to determine the effect of blood glucose reduction from bulbs of Bawang Dayak based on the use of different extraction methods using oral glucose tolerance test. Method: Dried sample was extracted with methanol using maceration, reflux, and Soxhlet method, respectively. The measurement of blood glucose reduction was performed using oral glucose tolerance test in vivo method and was analyzed using statistical comparison (Two-Way-ANOVA). Results: Based on the each extraction results was obtained yields of as 8.636\% (reflux method), 11.87\% (maceration method), and 14.023\% (soxhlet method). While the results of blood glucose lowering effect on each extract were used, there were significant differences in statistical tests and organ index. Conclusion: This result is a preliminary stage and the information is invaluable for further research.

}, keywords = {Bawang Dayak, Bulbs of plant, Eleutherine palmifolia L. Merr, Extraction method, Oral glucose tolerance test}, doi = {10.5530/pj.2018.1.10}, url = {http://fulltxt.org/article/365}, author = {Islamudin Ahmad and Neneng Siti Silfi Ambarwati and Niken Indriyanti and Yurika Sastyarina and Laode Rijai and Abdul Mun{\textquoteright}im} } @article {595, title = {Repairing Effects of Aqueous Extract of Kalanchoe pinnata (Lmk) Pers. on Lupus Nephritis Mice}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {March 2018}, pages = {548-552}, type = {Original Article}, chapter = {548}, abstract = {

Kalanchoe pinnata (Lmk) Pers (KP) has an immunosuppressive effect on delayed-type hypersensitivity test. Based on it, this research aimed to determine the repairing effects of aqueous extract of KP on lupus nephritis mice and identified its active compound. The KP extract profile was determined using UPLC-QTOF-MS/MS instrument. We examined six mice groups consisting of three curative treatment groups, one standard group receiving prednisone, one preventive group receiving KP extract, and one healthy (healthy and untreated) group. At the end of the experiment, we measured the proteinuria and renal histology parameters. To recognize the active compound in the KP profile, we performed in silico assays for the flavonoid compounds to bind to the glucocorticoid receptor. We played in silico tests for the flavonoid compounds to identify the active compound in the KP profile. We found the repairing effect of KP was detected in the kidney, demonstrated by its low proteinuria level and its better tissue structure. In the curative group, the urine protein level and its glomerular inflammation decreased. In the preventive group, the aqueous extract of KP could prevent lupus nephritis manifestations in the kidney. Bryophyllin A is the most active compound of the KP. However, further research is needed to understand the mechanism involved. We conclude, the aqueous extract, especially its bryophyllin A, have beneficial effects in repairing the function and tissue structure of lupus manifestations in mice kidney.

}, keywords = {Docking, Glomerulonephritis, Inflammation, Lupus, Proteinuria}, doi = {10.5530/pj.2018.3.89}, url = {http://fulltxt.org/article/522}, author = {Niken Indriyanti and Afrillia Nuryanti Garmana and Finna Setiawan} }