@article {862, title = {Antidiabetic Aptitude of Cordia sebestena and its Outcome on Biochemical Parameters, Serum Electrolytes, and Hematological Markers}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {418-423}, type = {Original Article}, chapter = {418}, abstract = {

Objective: The present study investigated the antidiabetic outcome of ethanolic extract of Cordia sebestena fruit (EECSF) in streptozotocin (STZ)-induced diabetogenic rodents and evaluated its consequence to improve the level of biochemical parameters, serum electrolytes level, and hematological indices along with its impact on body weight. Materials and Methods: The albino rodents were selected to observe oral glucose tolerance test by oral intake of aqueous glucose solution (4 g/kg, body weight) in normal rodents and assessment of blood glucose level after administration of EECSF at 100 and 200 mg/kg and standard drug glibenclamide at 0.6 mg/kg, body weight. Antidiabetic activity was estimated in the chronic biological model by STZ (65 mg/kg/i.p.)-induced diabetes in rodents escorted by the determination of blood glucose. Further pharmacological research was carried out to explore the effect of EECSF on body weight, variations in biochemical parameters including aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, and total protein, transformations in serum electrolytes such as Na+, K+, Cl-, and Ca2+ along with estimation of hematological indices such as red blood cells, white blood cells, hemoglobin, lymphocytes, neutrophils, eosinophils, and monocytes. Results: It was discovered that EECSF significantly lowered the blood glucose level of diabetic rodents along with enhancement in body weight. Correspondingly, EECSF significantly ameliorated the biochemical parameters, serum electrolytes, and hematological indices. Conclusion: The results demonstrated the antidiabetic potential of EECSF in STZ-induced diabetes in rodents, and it could be selected to benefit from diabetes and its affiliated complexities inclusive of anemia, diabetic nephropathy, retinopathy, neuropathy, and hepatitis.

}, keywords = {Anemia, Antidiabetic, Cordia sebestena, Glucose, Streptozotocin}, doi = {10.5530/pj.2019.11.65}, author = {Sachin Chaudhary and Harish Chandra Verma and Mandeep Kumar Gupta and Hitesh Kumar and Sudhansu Ranjan Swain and Ramesh Kumar Gupta and Abdel-Nasser El-Shorbagi} } @article {607, title = {Hepatoprotective Potential of Trichosanthes dioica Roxb in Hepatotoxicity Induced by Simvastatin and its consequences on Biochemical and Haematological Indices}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {June 2018}, pages = {720-724}, type = {Original Article}, chapter = {720}, abstract = {

Objective:To evaluate hepatoprotective activity along with hematological and defensive recital of Trichosanthes dioica Roxb against simvastatin induced hepatotoxicity in experimental rodents. Methods: In the present study, in- vivo hepatoprotective effect of 50\% methanolic fruit extract of Trichosanthes dioica Roxb (TME 200 and 400 mg/kg body weight) was evaluated using experimental model, simvastatin (20 mg/kg, p.o.), induced hepatotoxicity in experimental animals. The hepatoprotective activity was estimatedby interpreting using various biochemical parameters like SGOT, SGPT, ALP, total bilirubin, total protein and albumin along with the haematological and histopathological studies. Results: The treatment with TME significantly (P\<0.05-P\<0.001) and dose-dependently reversed simvastatin induced elevation in serum level ofSGOT, SGPT, ALP, total bilirubin and restored the total protein and albumin level. Furthermore, TME also signify the blood parameters at dose of 1000 and 2000 mg/kg and restored the body defense mechanism. The histological examination revealed that TME at dose of 200 mg/kg showed regeneration of hepatocytes around central vein with near normal liver architecture. Conclusion: The results of this study exhibited liver protective effect of Trichosanthes dioica Roxb against simvastatin induced liver injury and there by scientifically support its traditional use.

}, keywords = {Hepatocytes, Hepatotoxicity, Liver, Simvastatin, Trichosanthes dioica}, doi = {10.5530/pj.2018.4.120}, url = {http://fulltxt.org/article/658}, author = {Ramesh Kumar Gupta and Sudhansu Ranjan Swain and Jagannath Sahoo and Amresh Gupta and Sachin Chaudhary} }