@article {1444, title = {Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {8th June 2015}, pages = {5-5}, type = {Original Article}, abstract = {

Background: Cough variant asthma (CVA) is characterized by prolonged non productive cough which responds to bronchodilator therapy. None of herbal drug is reported to possess pharmacological activity against CVA. Objective: To investigate the pharmacological potential of ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF) against CVA as well as to develop an efficient screening model for CVA. Material and Method: Antitussive effect of EEWF was evaluated against nebulized aqueous solution of 0.1 g/ml of citric acid to determine the cough response. EEWF potential was finally accessed against aerosolic mixture of 0.3 g/ml of citric acid mixed with 0.1\% histamine and 2\% acetylcholine chloride to evaluate the convulsive latency, percentage protection and cough frequency against CVA. Results: EEWF at aerosolic dose of 6\% w/v exhibit decrease in of the average coughs frequency (4.83\±0.30) which is quite significant effect as compared to standard drug codeine. EEWF against aerosol induced CVA was found to exhibit a significant bronchoprotection of 41.75\% and decreases number of coughs (7.16\±0.47) at 200 mg/kg as compared to control (14.16\±0.60). Conclusion: EEWF at 200 mg/kg dose exhibited bronchoprotective and antitussive effects against aerosol induced CVA.

Keywords: Acetylcholine, Antitussive, Bronchoprotection, Citric acid, Cough, Cough variant asthma (CVA), Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF), Histamine.

}, keywords = {Acetylcholine, Antitussive, Bronchoprotection, Citric acid, Cough, Cough variant asthma (CVA), Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF), Histamine}, author = {Amit Kumar Srivastava and Srivastava Abhinav Siddharth and Nagar Hemant and Srivastava Rajnish and Deepa and Shukla Gaurav} } @article {73, title = {Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {01/2015}, pages = {296-299}, type = {Original Article}, chapter = {296}, abstract = {

Background: Cough variant asthma (CVA) is characterized by prolonged non productive cough which responds to bronchodilator therapy. None of herbal drug is reported to possess pharmacological activity against CVA. Objective: To investigate the pharmacological potential of ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF) against CVA as well as to develop an efficient screening model for CVA. Material and Method: Anti-tussive effect of EEWF was evaluated against nebulized aqueous solution of 0.1 g/ml of citric acid to determine the cough response. EEWF potential was finally accessed against aerosolic mixture of 0.3 g/ml of citric acid mixed with 0.1\% histamine and 2\% acetylcholine chloride to evaluate the convulsive latency, percentage protection and cough frequency against CVA. Results: EEWF at aerosolic dose of 6\% w/v exhibit decrease in of the average coughs frequency (4.83 \± 0.30) which is quite significant effect as compared to standard drug codeine. EEWF against aerosol induced CVA was found to exhibit a significant bronchoprotection of 41.75\% and decreases number of coughs (7.16 \± 0.47) at 200 mg/kg as compared to control (14.16 \± 0.60). Conclusion: EEWF at 200 mg/kg dose exhibited bronchoprotective and anti-tussive effects against aerosol induced CVA.

}, keywords = {Acetylcholine, Anti-tussive, Bronchoprotection, Citric acid, Cough, Cough variant asthma (CVA), Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF), Histamine.}, doi = {10.5530/pj.2015.5.8}, author = {Amit Kumar Srivastava and Srivastava Abhinav Siddharth and Nagar Hemant and Srivastava Rajnish and Deepa and Shukla Gaurav} }