@article {1197, title = {Molecules of Interest {\textendash} Karanjin {\textendash} A Review}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {June 2020}, pages = {938-945}, type = {Review Article}, chapter = {938}, abstract = {

Background: At the present time, several plants are largely contributing to the medical field due to its valuable use. Scientific evidence generated with their special inherent compounds gave more confidence to the scientific community. Pongamia pinnata (Linn.) is an Indian native plant and well exploited in Ayurvedic medicinal system. Concurrently, a few pieces of scientific research have been done to prove the therapeutic activity of this medicinal plant. The medicinal properties of this plant are most likely due to its principal active compound, karanjin. As a molecule of interest, karanjin is an antioxidant and also exerts other biological benefits. Karanjin has also been recognized to be used in agricultural and environmental management other than medicinal purposes. Objectives: This review aimed to provide a brief information on the chemical and biological properties of karanjin along with its traditional uses. It is also discusses the scientific evidences available for its various biological properties. Materials and Methods: Various databases such as Google, Google Scholar Scopus, Web of Science, Pubmed had been searched and the data was obtained. Results: The chemistry and reported biological properties of karanjin were highlighted. Karanjin revealed antidiabetic, anticancer, antioxidant, gastroprotective, anti-inflammatory, antibacterial and anti-Alzheimer{\textquoteright}s activities, and thus has several possible applications in clinical research. Conclusion: Therefore, further research may help in exploiting its properties and emergent phytopharmaceuticals based on it.

}, keywords = {Chemistry, Flavonoid, Karanja, Karanjin, Pharmacology, Pongam oil tree, Pongamia pinnata}, doi = {10.5530/pj.2020.12.133}, author = {Aina Akmal Mohd Noor and Siti Nurul Najiha Othman and Pei Teng Lum and Shankar Mani and Mohd Farooq Shaikh and Mahendran Sekar} } @article {1211, title = {Protective Effect of Natural Products against Chemotherapy-Induced Cardiotoxicity: A Review}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {1180-1189}, type = {Review Article}, chapter = {1180}, abstract = {

Background: Cancer is one of the diseases with high mortality rate recorded each year across the world. Its mainstay treatment is chemotherapy although they are largely toxic, causing severe adverse reactions including cardiotoxicity, nephrotoxicity and genotoxicity. Cardiotoxicity is unique to certain chemotherapeutic agents and occur via several mechanisms. It has been hypothesized that co-administration of natural products which may be cardioprotectant, together with chemotherapy can alleviate cardiotoxicity-induced by chemotherapy. Objectives: This review aimed to provide a brief information about the protective effect of natural products against chemotherapy-induced cardiotoxicity Methods: To complete this review, relevant literatures were searched from several scientific databases including Google, Google Scholar, Scopus, Web of Science and Pubmed. Results: In this paper, we have reviewed ten natural products (curcumin, mangiferin, naringenin, quercetin, 6-gingerol, lycopene, resveratrol, apigenin, proanthocyanidins and indole-3-carbinol), which have major influences in attenuating chemotherapy-drug induced cardiotoxicity. Apart from the cardioprotective effects, they tend to confer some synergistic effects with chemotherapeutic agents and therefore have the potential to be used as an adjunct. Conclusion: Though a panel of natural products demonstrate protective effects against cardiotoxicity in cells and animal models, their therapeutic potentials for clinical needs further investigation.

}, keywords = {Anticancer drugs, Cardioprotective, Cardiotoxicity, Chemotherapy, Natural products}, doi = {10.5530/pj.2020.12.166}, author = {Siti Nurul Najiha Othman and Pei Teng Lum and Siew Hua Gan and Shankar Mani and Mahendran Sekar} }