@article {1978, title = {Analysis of Royal Jelly Apis Cerana as Therapeutic Candidate in Cbavd Based on Bioinformatics Studies}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {March 2023}, pages = {175-182}, type = {Research Article}, chapter = {175}, abstract = {

Background: Apis cerana honey bee is a honey bee native to Asia that spreads from Afghanistan, China, and Japan to Indonesia. The productivity of Apis cerana honey bees can produce as much as 2-5 kg of honey per colony in a year. Royal jelly is the queen{\textquoteright}s nourishment, and it is produced by larvae, adult bees, young worker bees, and male bee larvae. CBAVD contributes to 1{\textendash}2\% of the 20{\textendash}25\% of males with subfertility. Aim: The objective of this study was to evaluate Royal Jelly Apis Cerana as a potential therapeutic candidate for CBAVD using a bioinformatics approach. Method: This research method consisted of converting nucleotides into amino acids, analyzing the three-dimensional structure of Apis Cerana Royal Jelly Protein, Ramachandran Plot Analysis, Analysis of Epitope and Allergen Proteins, and Analysis of Proteins that were antigens and toxins. Results: The research results were conducted on six three-dimensional Apis Cerana Royal Jelly bee protein structures and had very good validity based on the Ramachandran plot, GQME value, and QmeanDisCo value. In addition, this study also obtained the results of proteins that are epitope, antigenic, non-allergenic, and non-toxic. Conclusion: The findings of this study can be used as a basis for therapy against CBAVD.

}, keywords = {Apis Cerana, Bioinformatics, CBAVD, Public health., Therapeutic Candidates}, doi = {10.5530/pj.2023.15.26}, author = {Maslichah Mafruchati and Jonathan Makuwia} } @article {2146, title = {Analysis of the Impact of Heat Stress on Embryo Development of Broiler: A Literature Review}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {October 2023}, pages = {964-968}, type = {Review Article}, chapter = {964}, abstract = {

Temperature is an important factor in embryonic development because temperature plays a role in determining the overall development of the embryo. The effect of high temperature on the embryo will cause the embryo to make a defense by diverting some of its energy to form thermal homeostasis, which is a physiological response. The purpose of this study was to analyze heat stress on embryonic development. This study used a systematic literature review (SLR) following PRISMA guidelines and gathered the sample of papers through the PubMed databases using keywords categorized as heat, stress, and embryo. There were 31 papers used as samples. The result showed that hyperthermia in chickens caused an increase in heart rate per minute as a result of temperature pressure. It affects the hatching percentage, hatching time, weight, and mortality rate in chicken embryos. In summary, heat stress has an impact on embryonic development heat stress gives an impact on the development of embryos.

}, keywords = {Chicken, Embryo Development, Food security, Health risk, Heat Stress.}, doi = {10.5530/pj.2023.15.179}, author = {Maslichah Mafruchati and Nor Hayati Othman and Akhmad Kusuma Wardhana} } @article {1998, title = {The Aqueous Leaf Extract of Moringa Oleifera had Immunomodulatory Effects on Sheep that had Been Infected by Fasciola Gigantica, Clostridium Novyi Naturally and Impact to Fasciola gigantica Non-Embryonated}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {304-309}, type = {Original Article }, chapter = {304}, abstract = {

M., which received a (C), was the study{\textquoteright}s main objective. The whole thing was eaten. a couple of quotes from (C. dispersed in a liquid. has antibacterial properties (E. elegans). It{\textquoteright}s necessary to remove the body. C. Eczema on the face is comparable to this. Sheep and novyi both had organic infections. novyi. Following different combinations of treatments, a heavy dose of treatment, and a light dose, fasciolitis manifested in all three groups of infected sheep. The treatment groups received an oral 150 mg/kg aqueous M. oleifera leaf extract every 48 hours for 21 days. Body mass, fecal egg counts, blood anti-Fasciola IgG levels, cytokines (IL-2, IL-17, and IL-10), and C. the elegans{\textquoteright} bacterial inhabitants jokingly strike up a conversation with everyone there. Sheep with light and heavy infections gained more weight after receiving M. oleifera treatment and had lower fecal egg counts than control groups; sheep with light infection had a 100\% reduction in egg count. The serum concentrations of IL-2, IL-17, and IgG all significantly decreased after M. oleifera treatment. There were significantly higher levels of IL-10 in sheep with both mild and severe infections. C{\textquoteright}s feces contained noticeably fewer bacteria after taking moringa extract. The two novyi groups had varying degrees of infection severity. Fabricio (F. (as well as OleiferaMdot). C. noteworthy and novyi. M. oleifera aqueous extracts showed a concentration-dependent ovicidal effect on F. gigantica non-embryonated.

}, keywords = {Anthelmintic, Antimicrobial, Cytokines, Moringa oleifera, Public health.}, doi = {10.5530/pj.2023.15.44}, author = {Maslichah Mafruchati and Wan Irjani Wan Ismail} } @article {2092, title = {RETRACTED: Human Sperm for Basic Embryo Research And 3D Treatment of Patient-Representative Ovarian Cancer Cells}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {August 2023}, pages = {626-632}, type = {Research Article}, chapter = {626}, abstract = {

The article has been retracted based on the authors{\textquoteright} request.

}, keywords = {3D treatment, Basic embryo research, Human sperm, Ovarian cancer cells, Public health.}, author = {Maslichah Mafruchati and Wan Irjani Wan Ismail} } @article {1766, title = {Potential of Stem Cells in Overcoming Infertility Problems in Women}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {April 2022}, pages = {296-300}, type = {Original Article}, chapter = {296}, abstract = {

Stem cells are characterized as cells with undifferentiated kinds that have the ability to differentiate into a variety of various cell types in response to the environment in which they are growing and develop (niche). Stem cells are classified into three broad categories based on their origin: extra-embryonic stem cells, which are derived from the amniotic fluid, umbilical cord and placenta; adult stem cells, which are derived from adult tissues such as blood, fat, bone marrow and skin; and embryonic stem cells, which are derived from the blastocyst. Stem cells exposed to certain suitable conditions will differentiate into 3 germ layers and also primordial germ cells. This is the basis for the latest research to obtain mature haploid gametes capable of developing into normal embryos and fetuses. Somatic Nuclear Cell Transfer (SNCT) technique is used to produce mature gametes so that the resulting cells contain cell nuclei with new genetic material. Infertility is a common problem that occurs with a prevalence of 10-15\% of couples of reproductive age. Causes of infertility in women include metabolic and hormonal disorders accompanied by interactions with environmental factors that reduce oocyte quality. This results in an increased rate of aneuploidy in the resultant oocytes and impairs the human implantation process. The main objective of this research is to enhance the understanding of stem cells in women{\textquoteright}s infertility. The method used in writing this review article is online literature studies obtained by accessing national and international scientific journals as well as scientific articles related to stem cells (Stem cells), infertility, women. From the results of this study, it can be seen the potential of stem cells (stem cells) in treating infertility in women. Further studies are needed, especially pre-clinical and clinical trials so that they can be widely applied.

}, keywords = {Health risk, Infertility therapy, Public Health, Somatic cell nuclear transfer (SNCT), Stem Cells}, doi = {10.5530/pj.2022.14.37}, author = {Maslichah Mafruchati and Jonathan Makuwia} } @article {1839, title = {Protein Analysis of Royal Jelly Bee Apis Mellifera Carpatica as Candidates for Immunotherapy in Reproductive Disorders}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {August 2022}, pages = {338-343}, type = {Original Article }, chapter = {338}, abstract = {

Background: The honey bee of the Apis mellifera species is the main type of bee cultivated in almost all countries in the world, including Indonesia. Honey has benefits in various aspects, including food, health, and beauty. Royal jelly is a daily food menu as a food supplement to maintain and increase health and vitality. Purpose: Analyzing the immunogenic and toxinogenic proteins of Royal jelly Apis mellifera carpatica as immunotherapy. Method: Conversion of nucleotides into amino acids. Royal jelly Apis mellifera carpatica, analysis of the three-dimensional structure of Protein of Royal jelly Apis mellifera carpatica, Analysis of Ramachandran Plots of Royal jelly Apis mellifera carpatica, Analysis of epitope and allergen proteins, Analysis of antigens and toxins. Research result: The research results found that six proteins of Royal jelly Apis mellifera carpatica were epitope, antigenic, and non-toxic. Allergens and three Royal jelly proteins, Apis mellifera carpatica, are non-allergenic. In this study, the three-dimensional structure has not been found and opens opportunities for proteomic studies of the Royal jelly Apis mellifera carpatica protein, including protein isolation. Conclusion: The findings of this study can be used as a basis for the use of immunotherapy materials against the protein Royal jelly Apis mellifera carpatica against reproductive disorders.

}, keywords = {Analysis, Apis mellifera carpatica, Immunotherapy, Protein, Royal jelly}, doi = {10.5530/pj.2022.14.104}, author = {Maslichah Mafruchati and Jonathan Makuwia} } @article {1659, title = {Analysis of Three-Dimensional Protein Structure of CBAVD in Indonesia as a Basis for Immunotherapy to Ensure Maternal Health}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1282-1286}, type = {Research Article}, chapter = {1282}, abstract = {

Introduction: Congenital Bilateral Advance Vass Deferens (CBAVD) is a birth defect characterized by azoospermia. Determine the protein structure by laboratory research was relatively difficult. The threedimensional structure of proteins is computationally analyzed as an excellent and cost-effective alternative to analyzing protein characteristics. Objective: This study has an objective to identify the three-dimensional protein structure of CBAVD in Indonesia so that it can be used to obtain drugs and immunotherapy. Method: This study uses method of DNA extraction, PCR, and sequencing in collecting the data sample. The data was analyzed using using expasy software and Swiss prot. Result: The results of this study were found 6 CBAVD proteins, four to three dimensional CBAVD protein structures and 2 CBAVD proteins that have not been identified by the three dimensional protein structure. Further studies of CBAVD protein are needed, especially those related to protein isolation and crystallography. Conclusion: The three dimensional protein can be used as immunotherapy to ensure the maternal health.

}, keywords = {CBAVD, Dimensional structure, Maternal health, Protein}, doi = {10.5530/pj.2021.13.162}, author = {Maslichah Mafruchati and Jonathan Makuwira} } @article {1623, title = {Number of research papers about Agricultural production, Meat, and Egg During COVID-19 Pandemic: Does it Changed than Before?}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {995-998}, type = {Research Article}, chapter = {995}, abstract = {

COVID-19 pandemic limits many physical activities of the society in public areas. The agricultural production sector is one of the important sectors in supporting the country{\textquoteright}s nutrition demand. Research is a way to maintain the productivity of the agricultural sector. This study has a purpose to analyze if pandemic COVID-19 has an impact on the number of papers about agriculture recorded by Scopus. This study uses a quantitative with secondary data analysis approach in collecting data. The samples are paper on the Scopus website contains keywords {\textquotedblleft}agriculture\& meat{\textquotedblright}, and {\textquotedblleft}agriculture\&egg{\textquotedblright}. the period of samples are during 2019-2020. The data are analyzed using Vosviewer software to show the institution with the most related topic paper. The result shows that some papers are decreasing while others are increase based on the document type. For paper related to {\textquotedblleft}agriculture{\textquotedblright} meat{\textquotedblright}, article as full type research paper increases along with review type paper. For a paper about {\textquotedblleft}agriculture \& egg{\textquotedblright}, conference type paper and review increase, while other decreases. It can be concluded that the type of paper along with the topic affects the institutions{\textquoteright} productivity in publishing papers

}, keywords = {Agricultural production, COVID-19, Egg, Meat, Research papers}, doi = {10.5530/pj.2021.13.128}, author = {Maslichah Mafruchati and Jonathan Makuwira} }