@article {821, title = {Cinnamon species: In vivo Anti-Oxidant Activity of Ethanolic Extracts of Cinnamon Zeylanicum and Cinnamon Cassicae Barks}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {245-247}, type = {Original Article}, chapter = {245}, abstract = {

Background: The diabetic population is increasing highly in the worldwide due to the poor control of diabetes and environmental conditions. It disturbs the carbohydrate, protein and lipid metabolism. The natural medicines obtained from the plant source may be the effective treatment of diabetes. Objective: The aim of the present study is to investigate the antioxidant activities of the ethanolic bark extract of Cinnamon zeylanicum and Cinnamon cassiacae. in streptozotocin (STZ) induced oxidative stress in rats. Methods: Oxidative stress is induced with a single dose of STZ 60 mg/kg b.w. and then the animals are treated with a dose of various concentrations of ethanolic bark extract of Cinnamon zeylanicum and Cinnamon cassiacae (200 mg/kg b.w, 400 mg/kg b.w, and 600 mg/ kg b.w) for 45 days. After the treatment lipid peroxides (LPO), reduce glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) levels are determined. Glibenclamide is used as a standard drug (3 mg/kg b.w.). Results: The present study exposed that the administration of ethanolic bark extract of Cinnamon zeylanicum and Cinnamon cassiacae showed a significant decrease in LPO levels. The treatment also finds that the significant increase in GSH, GPx, SOD and CAT levels in the liver, when compared with diabetic control rats. Conclusion: The results proved that the ethanolic bark extract of Cinnamon zeylanicum and Cinnamon cassiacae treated group may effectively regulate the antioxidant status in STZ induced diabetic treated groups.

}, keywords = {Anti-oxidant activity, Cinnamon cassicae, Cinnamon zeylanicum, Diabetes mellitus, Streptozotocin}, doi = {10.5530/pj.2019.11.38}, author = {Balasubramanian Prasanna and Arumugam Vijaya Anand} } @article {853, title = {Protective Effect of Terminalia catappa Leaves and Terminalia chebula Fruits on the Enzymatic and Non-enzymatic Anti-oxidant Levels in the Doxorubicin Induced Toxicity Rats}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {346-349}, type = {Original Article}, chapter = {346}, abstract = {

Background: Oxidative stress plays an important role in chronic complications of diabetes, cancer, liver disorder etc. The free radicals such as superoxide anions, hydrogen peroxides are causing the oxidative stress and it involves the cellular damage. Evidences recommended that the natural medicines from plant sources are treated to overcome the oxidative stress complications. Objective: The aim of the present is to find the antioxidant activity of the ethanolic extract of Terminalia catappa leaves and Terminalia chebula fruits in the doxorubicin (DOX) induced toxicity rats. Methods: Oxidative stress is induced with a single dose of doxorubicin and then the animals were treated with a dose of various concentration of ethanolic extract of T. catappa leaves and T. chebula fruits (200, 300 mg/kg/b.w) for 21 days. After the treatment, lipid peroxide (LPO), reduced glutathione (GSH), vitamin C, vitamin E, glutathiones- transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase levels are determined. Propranolol 25mg/kg is used as standard drug. Results: In the present study, after the treatment of doxorubicin the levels of SOD, CAT, GSH, GST, GPX, vitamin C, vitamin E levels are decreased and LPO level is increased. After the treatment of T. catappa leaves and T. chebula fruits the levels were returned to the normal level. Conclusion: The results proved that the ethanolic extract of T. catappa leaves and T. chebula fruits may protects the cells from oxidative stress induced by the doxorubicin induced toxicity rats.

}, keywords = {Doxorubicin, Enzymatic antioxidant, Non-enzymatic antioxidant, Oxidative stress, Termianlia catappa, Terminalia chebulla.}, doi = {10.5530/pj.2019.11.51}, author = {Panneerselvam Punniyakotti and Rengasamy Lakshminarayanan Rengarajan and Shanmugam Velayuthaprabhu and Kalaiyarasan Vijayakumar and Ramasamy Manikandan and Arumugam Vijaya Anand} } @article {537, title = {Impact of Tridax procumbens on Hematological Parameters in aflatoxin Induced Liver Toxicity in Albino Rats}, journal = {Pharmacog Journal}, volume = {10}, year = {2018}, month = {January-2018}, pages = {304-308}, type = {Original Article}, chapter = {304}, abstract = {

Objective: Tridax procumbens comes under the family Asteraceae Tridax which is found to have anti-inflammatory, analgesic properties. Materials and Methods: The morphological parameters such as the body weight, liver and kidney weight of experimental animals which were fed by alfatoxin and thereby treating with extracts of T. procumbens were studied along with the Hematological parameters such as Haemoglobin (Hb), Red Blood Corpus Cells (RBC), White Blood Corpus Cells (WBC) , Packed Cell Volume (PCV) and Prothrombin time (PT). Results: The results of this study shows that there is an significant changes in the body weight liver and kidney weight in T. procumbens treated animals and also significant raise in blood level was seen in the T. procumbens treated animals. Conclusion: Based on the results obtained, we concluded that T. procumbens have an antiaflatoxicosis potency.

}, keywords = {alfatoxin, etc, Haemoglobin, Packed cell volume, Prothrombin time, Red blood corpus cells, Tridax procumbens, White blood corpus cells}, doi = {10.5530/pj.2018.2.53}, url = {http://fulltxt.org/article/483}, author = {Palanisamy Sampathkumar and Subramanian Kalavathy and Arumugam Vijaya Anand and Thangavelu Sangeetha and Purusothaman Sujeetha} } @article {171, title = {Phytochemical and In vitro Antidiabetic Activity of Psidium Guajava Leaves}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {June/2016}, pages = {392-394}, type = {Original Article}, chapter = {392}, abstract = {

Objective: The present investigation includes the preliminary screening of phytochemicals and evaluation of in vitro antidiabetic activity of Psidium guajava leaves extracts. Materials and Methods: Plant material was subjected to the extraction preparation by soxhlet apparatus by using various solvents such as aqueous, ethanol, chloroform, petroleum ether and hexane. The various kinds of phytochemicals were detected and then in vitro antidiabetic activity of P. guajava were detected by using alpha amylase and alpha glucosidase enzyme in an in vitro model. Results: The study reveals the presence of phytochemicals such as carbohydrate, tannin, flavonoids, phenols etc., Among the various extracts the aqueous and ethanolic extracts which contains the large number of phytoconstituents. The P. guajava leaves has been successfully inhibited both the enzymes in an in vitro model. The aqueous extracts of P. guajava leaves inhibited the alpha amylase and alpha glucosidase enzymes as 72.1\% and 74.8\% respectively. The ethanolic extract of P. guajava leaves inhibited the alpha amylase and alpha glucosidase enzymes as 97.5\% and 91.8\% respectively. Conclusion: From the results obtained in the current studies, the P. guajava leaves have a prominent antidiabetic property in an in vitro model and further studies can be carried out in an in vivo model and the isolation of activie compound from P. guajava leaves extract is needed.

}, keywords = {Alpha amylase, Alpha glucosidase, P. guajava, Phytochemical.}, doi = {10.5530/pj.2016.4.13}, author = {Ramasamy Manikandan and Arumugam Vijaya Anand and Sampath Kumar and Pushpa} }