@article {430, title = {Total Phenolic Contents and Free Radical Scavenging Activity of Guaiacum officinale L. Extracts}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {929-931}, type = {Original Article}, chapter = {929}, abstract = {

Backgound: Guaiacum officinale L. is an alien species to Thailand. It is used as anti-arthritis and anti-rheumatoid agents in Indian folklore medicine. Objective: The present study was aimed to investigate total phenolic contents and free radical scavenging activity of the extracts from Guaiacum officinale L. (Zygophyllaceae). Methods: The plant parts including bark, twig and leaf were extracted using different solvents (ethyl acetate, water and ethanol). Total phenolic contents were determined by Folin-Ciocalteu Colorimetry method while free radical scavenging activity of the extracts was investigated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Results: The results show that the highest total phenolic content is found in the ethyl acetate twig extracts (20.3\±0.0031 \μg GAE/1 \μg extracts). The ethanolic twig extracts had the highest free radical scavenging activity with IC50 of 0.45\±0.0188 mg/ml. Conclusion: The extracts from Guaiacum officinale L. exhibit good anti-oxidant activity and may be suitable for development as drugs and supplementary food.

}, keywords = {Ethanolic twig extracts, Ethyl acetate twig extracts., Free Radical Scavenging Activity, Guaiacum Officinale L, Total Phenolic Contents}, doi = {10.5530/pj.2017.6.145}, url = {http://fulltxt.org/article/198}, author = {Suthira Maneechai and Vachiraporn Pikulthong} } @article {1487, title = {Chemical Constituents of Dendrobium williamsonii}, journal = {Pharmacognosy journal}, volume = {6}, year = {2014}, month = {8th April 2014}, pages = {36-41}, type = {Original Article}, abstract = {

Objective: Isolation of compounds from Dendrobium williamsonii and evaluation of each isolates for its free radical scavenging, antiherpetic and cytotoxic activities. Results: Six phenolic compounds were isolated including tetratriacontanyltrans- p-coumarate (1), trans-docosanoylferulate (2), 3,3\′-dihydroxy-4,5-dimethoxybibenzyl (3), moscatilin (4), apigenin (5) and vanillic acid (6). Among these isolates, compounds 3, 4 and 5 exhibited recognizable DPPH free radical scavenging potential.Only 3 exhibited weak activity against Herpes simplex virus, whereas 3 and 4 showed cytotoxicity against KB and MCF-7 cancer cells. Conclusion: This study is the first report on the chemical and biological properties of D. williamsonii.Compounds 3, 4 and 5 are responsible for free radical scavenging activity of this plant. Compound 4 showed the strongest cytotoxic effect on KB cancer cells.

Key words:Dendrobium williamsonii, Orchidaceae, Anti-herpetic Cytotoxicity, Free radical scavenging activity.

}, keywords = {Anti-herpetic Cytotoxicity, Dendrobium williamsonii, Free Radical Scavenging Activity, Orchidaceae}, author = {Pathrapa Rungwichaniwat and Boonchoo Sritularak and Kittisak Likhitwitayawuid} }