@article {1807, title = {In Vivo Studies of Combined Probiotics on IFN-γ, Ig-E and Bronchial Muscular Layer of Rats with Allergic Asthma}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {June 2022}, pages = {598-603}, type = {Research Article}, chapter = {598}, abstract = {

Background: Leuconostoc mesenteriodes and Lactobacillus brevis are being used as probiotic to improve the immune system. The effect of probiotic containing combination of the 2 bacteria on enhancing innate and adaptive immune responses is not fully understood. Objective: This was conducted to analyse the effect of probiotic containing in single or combination content of L. mesenteriodes (Lm) and L. brevis (Lb) on IFN-γ concentration, Ig-E concentration, and histopathology of bronchial muscular layer of ovalbumininduced allergic asthma. Materials and Methods: A total of 40 male Sprague Dawley rats (6{\textendash}8 weeks, 200-300 g) were randomly divided into 5 groups: NC (non-induced control group); NgC (OVA-induced control group), Lm (OVA +probiotics containing L. mesenteriodes), Lb (OVA + probiotics containing L. brevis), and Lm + Lb (OVA+probiotics containing combination of L. mesenteriodes and L. brevis). On 64-day, concentration of IFN-γ and Ig-E in serum were measured. Histology of bronchus was performed. Results: IFN-γ concentration, Ig-E The administration of single or combined probiotics increased IFN-γ (p\<0.001), yet decreased IgE (p\<0.001) of all treatment groups, but only a combination of both probiotics reduced the thickness of the bronchial epithelium. Conclusion: The combination of Lm and Lb single or combined probiotics improve systemic and local anti-inflammation effects and ameliorate airway remodelling in the ovalbumin-induced chronic asthma rat model.

}, keywords = {Asthma, Bronchus histopatology, IFN-γ, Ig-E, Lactobacillus brevis, Leuconostoc mesenteriodes}, doi = {10.5530/pj.2022.14.77}, author = {Pujiati Pujiati and Soetrisno and Dono Indarto and Reviono} } @article {1406, title = {A Few Potential Treatments of Asthma in Vietnam}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {640-643}, type = {Original Article}, chapter = {640}, abstract = {

Asthma is a chronic condition that can be fatal if it isn{\textquoteright}t treated promptly during an attack. Patients with an asthma attack cannot breathe enough air to supply the body with oxygen and within minutes, the patient can die. In Vietnam today, people can buy antibiotics on their own without the need of a doctor to prescribe or visit. Many people who only see signs of coughing, wheezing have voluntarily bought antibiotics for use. The overuse of antibiotics is very common in asthma patients. In fact, antibiotics are not effective in most types of asthma. Abuse of antibiotics is not only ineffective, but also makes the patient more tired, reduces resistance, and digestive disorders. Some antibiotics can even lead to acute asthma attacks. This article covers some of the remedies that can eradicate asthma with a combination of several fairly safe treatments. Through analysis of the scientific composition and current studies, it is possible to treat asthma and maintain good health.

}, keywords = {Asthma, Health, Medicine, Patient, Prevention}, doi = {10.5530/pj.2021.13.81}, author = {Huynh Tan Hoi} } @article {1534, title = {15-Lipoxygenase inhibition of selected Philippine medicinal plants}, journal = {Pharmacognosy Journal}, volume = {6}, year = {2014}, month = {18th Feb,2014}, pages = {43-46}, type = {Original Article}, abstract = {

Several extracts from Philippine medicinal plants used for asthma and other inflammatory diseases were evaluated for their ability to inhibit the action of 15-lipoxygenase. The inhibitory activity was tested spectrophotometrically using quercetin as positive control. Eleven species belonging to 11 families displayed varying inhibitory activities. Commelina diffusa and Euphorbia hirta showed the highest inhibitory activity at 51.3\% and 48.5\%, respectively. These plants may contain new 15-lipoxygenase inhibitors.

Key words: Asthma, inflammation, lipoxygenase, medicinal plants, plant extra.

}, keywords = {Asthma, Inflammation, Lipoxygenase, Medicinal plants, Plant extracts}, author = {Noemi D. Paguigan, and Christine L. Chichioco-Hernandez,} }