@article {854, title = {Assessment of Phyto-Constituents by GC-MS and Anti-Tumour Activity of Garlic Grown in Different Altitude: A Comparative Study}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {350-354}, type = {Original Article}, chapter = {350}, abstract = {

Background: Garlic (Allium sativum L.) is most important spice containing highest sources of total phenolic compounds. It has been used as a component of traditional and modern medicine. Pharmacological properties of garlic is mainly depend on its phyto-constituents content, which varies between geographical regions. The aim of this study was to evaluate and compare the phyto-constituents content of garlic sample collected from high ranges of Idukki (Kanthallur) with that of Tamil Nadu (Mettupalayam market) garlic sample. Materials and Methods: garlic clove sample were collected from high ranges of kanthallur region (GSK) and Mettupalayam region (GSM). The garlic oil was extracted from the collected garlic sample by solvent extraction method. The phytochemical study of extracted garlic oil were conducted using standard methods of analysis and subjected GC-MS analysis. Further, the extracted oil samples were studied for their anti-tumour activity against Dalton Lymphoma Cell Lines (DLA) in an in vitro model. Results: The obtained results revealed that garlic oil of GSK showed highest percentage of yield of oil (1.1\%) than garlic oil of GSM (0.6\%). The phytochemical screening of GSK indicated the presence of alkaloids and flavonoid, whereas GSM showed presence of alkaloids only. GC-MS analysis of garlic oil study indicated that garlic oil of GSK was found to have eugenol as a novel source compared with garlic oil of GSM. Garlic oil of GSK showed significant anti-tumour activity against DLA cells, compared with garlic oil of GSM. Conclusion: Garlic oil of GSK exhibited potential anti-tumour activity against DLA cells due to presence of eugenol compound as novel source.

}, keywords = {Anti-tumour, Garlic oil, GC-MS, MTT, Phyto-constituents}, doi = {10.5530/pj.2019.11.52}, author = {Susha Antony and Kunnambath Krishna Kumar and Jalaja Sudhi Menon} } @article {173, title = {Health Benefits of Morinda citrifolia (Noni): A Review}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {June/2016}, pages = {321-334}, type = {Review Article}, chapter = {321}, abstract = {

Background: Morinda citrifolia (Noni) has been used widely as a complementary and alternative therapy in many countries owing to its potent antioxidant activity and proven health benefits. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, anti-inflammatory, immunostimulant. Also it has proved beneficial in conditions like gastritis, skin diseases, respiratory infections, menstrual and urinary tract disorders, fever, diabetes and venereal diseases. Objective: This review emphasizes on the phytochemical and mineral profile of the different parts of Noni plant. In addition, this review corroborates the pharmacological basis for the various health benefits, traditional and medicinal applications of Noni. Materials and Methods: All the available information of Noni were collected from electronic databases such as Academic Journals, Ethnobotany, Ethnopharmacology, Springer, PubMed, Google Scholar, Science Direct and other primary and secondary sources. Results: According to our search results pertaining to scientific literature, Morinda citrifolia is used for more than 40 types of ailments worldwide. Crude extract of various parts of plant and fruit juice are reported to contain amino acids, anthraquinones, fatty acids, flavonoids, iridoids, lignans, polysaccharides, sterols, sugars, terpenoids etc. which are therapeutically useful for a broad range of pathological conditions. Fourteen human clinical trials have validated the remarkable health benefits of Noni. Conclusion: Literatures prove that Noni is pharmacologically active and is used in different forms of cancer, viz. colon, esophageal, breast, colorectal cancers; cardiovascular diseases, diabetes, arthritis, hypertension. These properties are substantiated by the preclinical or/and clinical investigations.

}, keywords = {Anticancer., Antioxidant, Morinda citrifolia, Neutraceutical, Phyto-constituents}, doi = {10.5530/pj.2016.4.4}, author = {Mohammad Ali and Mruthunjaya Kenganora and Santhepete Nanjundaiah Manjula} }