@article {1939, title = {Job fulfilment and its related variables among pharmacy certificate holders in Jordan: A Cross-sectional Study}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {January 2023}, pages = {983-988}, type = {Research Article }, chapter = {983}, abstract = {

Background: The feeling of contentment one has with their job is referred to as job satisfaction. The quality of health care, processes, and services are directly impacted by pharmacists{\textquoteright} job satisfaction, which is a key factor in influencing their motivation. Nevertheless, there hasn{\textquoteright}t been much research done to evaluate the employment satisfaction of Jordanian pharmacists working in various professions and locations. This study assessed the job satisfaction level among all pharmacy certificate carriers (Doctor of pharmacy, pharmacists, clinical pharmacists, industrial pharmacists, academic pharmacists, and assistant pharmacists) in Jordan and the elements that influence their level of job satisfaction which finally affect their job performance and employee turnover. Methods: This cross-sectional inquiry comprised Jordanian pharmacy certificate holders. Online national surveys on job satisfaction were conducted using a reputable, well-designed questionnaire. The questionnaire has 22 criteria for measuring job satisfaction. Logic regression analyses were utilized in order to examine the relationship between sociodemographic variables, work satisfaction indicators, and overall job satisfaction levels. Results: The study received responses from 236 pharmacy certificate holders. The mean introducing age was middle age (30-39yrs) (52.6\%), with the majority being females (87.5\%). The overall job satisfaction level reported by participants had a mean score of 2.97, with 14.4\% of them being satisfied with their jobs. Salary and a lack of promotion opportunities were found to be significantly related to overall job satisfaction (p = 0.001, p=0.011 respectively). Conclusion: The majority of Jordanian pharmacy certificate holders were dissatisfied with their jobs. Increasing salary and advancement opportunities would increase job satisfaction among pharmacy certificate holders in the country. There is a need for effective human resource management and policy revision in the pharmacy sector in Jordan.

}, keywords = {Employee turnover., Job satisfaction, Pharmacy certificate holders}, doi = {10.5530/pj.2022.14.200}, author = {Noha Abd Alkareem Younis Younis} } @article {1480, title = {Jackfruit (Artocarpus heterophyllus) seed extract exhibits fibrino(geno)lytic activity}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {09th Mar, 2015}, pages = {171-177}, type = {Original Article}, chapter = {171}, abstract = {

Objective: The current study assesses the fibrinogen and fibrin clot hydrolyzing activities of aqueous seed extract of Jackfruit (AqSEJ). Methods: The protein banding pattern of AqSEJ (100 \μg) was analyzed on SDS-PAGE. The proteolytic activity of AqSEJ was confirmed by spectrophotometer and zymography experiments. Fibrinogen, fibrin and plasma protein hydrolyzing activities of AqSEJ were analyzed on SDS-PAGE under reduced conditions. Plasminogen activation and indirect hemolytic activities was analyzed using spectrophotometer. The non-toxic property of AqSEJ was tested by edema, hemorrhage in experimental mice. Results: AqSEJ exhibited proteolytic activity and the specific activity was found to be 1.04 units/mg/min. Furthermore, AqSEJ non-specifically hydrolyzed A\α, followed by B\β and \γ chains of human fibrinogen and specifically hydrolyzed \α polymer and \α chain of partially cross linked human fibrin clot without affecting \β chain and \γ-\γ dimer even up to the tested dose of 30 \µg for the incubation period of 8 hours. Importantly, AqSEJ did not hydrolyze other plasma proteins and devoid of plasminogen activation property. The proteolytic activity of AqSEJ was completely neutralized by PMSF and IAA, while EDTA, EGTA, 1,10-Phenanthroline did not, suggesting the presence of serine and cysteine family proteases. Moreover, AqSEJ did not cause edema and hemorrhage in experimental mice up to the tested dose of 200 \µg and nontoxic to RBC cells. Conclusion: AqSEJ hydrolyzes fibrinogen and fibrin clot and non-toxic in nature. Hence, this work showcases the potential applications of Jack fruit seed proteases in the treatment of thrombotic disorders.

Key words: Fibrino(geno)lysis, Hemostasis, Jackfruit, Moraceae, Non-hemorrhagic, Serine/cysteine protease.

}, keywords = {Fibrino(geno)lysis, Hemostasis, Jackfruit, Moraceae, Non-hemorrhagic, Serine/cysteine protease.}, author = {Sowmyashree Gangaraju and Bhagyalakshmi Manjappa and Girish Kesturu Subbaiah and Kemparaju Kempaiah} } @article {49, title = {Jackfruit (Artocarpus heterophyllus) seed extract exhibits fibrino(geno)lytic activity}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {01/2015}, pages = {171-177}, type = {Original Article}, chapter = {171}, abstract = {

Objective: The current study assesses the fibrinogen and fibrin clot hydrolyzing activities of aqueous seed extract of Jackfruit (AqSEJ). Methods: The protein banding pattern of AqSEJ (100 \μg) was analyzed on SDS-PAGE. The proteolytic activity of AqSEJ was confirmed by spectrophotometer and zymography experiments. Fibrinogen, fibrin and plasma protein hydrolyzing activities of AqSEJ were analyzed on SDS-PAGE under reduced conditions. Plasminogen activation and indirect hemolytic activities was analyzed using spectrophotometer. The non-toxic property of AqSEJ was tested by edema, hemorrhage in experimental mice. Results: AqSEJ exhibited proteolytic activity and the specific activity was found to be 1.04 units/mg/min. Furthermore, AqSEJ non-specifically hydrolyzed A\α, followed by B\β and \γ chains of human fibrinogen and specifically hydrolyzed \α polymer and \α chain of partially cross linked human fibrin clot without affecting \β chain and \γ-\γ dimer even up to the tested dose of 30 \µg for the incubation period of 8 hours. Importantly, AqSEJ did not hydrolyze other plasma proteins and devoid of plasminogen activation property. The proteolytic activity of AqSEJ was completely neutralized by PMSF and IAA, while EDTA, EGTA, 1,10-Phenanthroline did not, suggesting the presence of serine and cysteine family proteases. Moreover, AqSEJ did not cause edema and hemorrhage in experimental mice up to the tested dose of 200 \µg and non-toxic to RBC cells. Conclusion: AqSEJ hydrolyzes fibrinogen and fibrin clot and non-toxic in nature. Hence, this work showcases the potential applications of Jack fruit seed proteases in the treatment of thrombotic disorders.

}, keywords = {Fibrino(geno)lysis, Hemostasis, Jackfruit, Moraceae, Non-hemorrhagic, Serine/cysteine protease.}, doi = {10.5530/pj.2015.3.5}, author = {Sowmyashree Gangaraju and Bhagyalakshmi Manjappa and Girish Kesturu Subbaiah and Kemparaju Kempaiah and Rangaiah Shashidharamurthy and Jane Hoover Plow and Sebastin Santhosh Martin and Manohar Shinde and Devaraja Sannaningaiah} }