02439nas a2200253 4500008004100000245014900041210006900190260001300259300001200272490000600284520156700290653002501857653001201882653001801894653003101912653001801943100003601961700003201997700003202029700003202061700002602093700003202119856003402151 2016 eng d00aStudy of Quality Assurance For Peumus Boldus M Products By Botanic Profiling, Extraction Optimization, HPLC Quantification And Antioxidant Assay0 aStudy of Quality Assurance For Peumus Boldus M Products By Botan cJan/2016 a264-2720 v83 a

Introduction: The boldo leaf has several traditional folk medicinal uses, such as for gallbladder, hepatic problems, digestive disorders, rheumatism and others. In the work reported herein, botanic profiling, extraction optimization by Soxhlet, quantification of boldine by an easy/simple to run HPLC method and antioxidant assay are proposed for the quality assurance of boldo dried leaves, standardized extracts, dried extracts, tablets and capsules. Materials and Methods; In this present work we are studying a systematic approach in the quality assurance study of quality assurance for Peumus boldus M products by the ascertainment of pharmacobotanic parameters for boldo identification, investigation of the extraction parameters by Soxhlet method, development and validation of an easy/simple to run HPLC method to quantify boldine in the raw drug, extracts, commercial tablets, capsules and coated tablets, and antioxidant assay. Results: The plant material was submitted to a pharmacognostic evaluation through morpho-anatomical diagnosis, showing that starlike trichomes can be used for boldo authentication. The HPLC validated analytical method is reliable, accurate and precise for boldine quantification. Furthermore, the Soxhlet extraction conditions were optimized. Conclusion: The methods proposed in this paper can be used for the quality assurance of boldo dried leaves, standardized extracts, dried extracts, tablets and capsules.

10aantioxidant activity10aBoldine10aPeumus boldus10aPharmacognostic evaluation10aQuantitation.1 aTeixeira, Cristiane, Cardoso Co1 aCabral, Tatiana, Pereira de1 ade Sousa, João, Paulo Barr1 aTeixeira, Simone, de Pádua1 aBastos, Jairo, Kenupp1 ade Freitas, Luis, Alexandre uhttp://phcogj.com/article/147