01807nas a2200217 4500008004100000245010400041210006900145260001700214300001200231490000600243520113800249653001601387653002101403653002401424653001601448653001401464100002001478700002901498700002901527856003301556 2015 eng d00aHepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in Rats0 aHepatoprotective Activity of Michelia nilagirica against Paracet cJul-Aug 2015 a228-2350 v73 a
Background: Michelia nilagirica belonging to the family Mangoliaceae is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. Objective: Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. Materials & Methods: Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. Results: The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) & Serum bilirubin. Conclusion: Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.
10aAlbino rats10aHepatoprotective10aMichelia nilagirica10aParacetamol10aScreening1 aAminabee, Shaik1 aRao, Atmakuri, Lakshmana1 aEswaraiah, Maram, Chinna uhttp://phcogj.com/article/56