TY - JOUR T1 - Hepatoprotective Effect of Bioactive Fraction of Lagerstroemia speciosa (L.) Pers. Bark Against Monosodium Glutamate-Induced Liver Toxicity JF - Pharmacognosy Journal Y1 - 2020 A1 - Lal Chand Pal A1 - Anil kumar A1 - Veena Pande A1 - Ch V Rao KW - Apoptosis KW - Lagerstroemia speciosa KW - Monosodium glutamate KW - Superoxide dismutase AB -

Background: The phenolics and flavanoid enriched bioactive fraction of L. speciosa bark were reported for its medicinal value in various illness however hepatoprotective activity against monosodium glutamate-induced liver toxicity yet to be reported. Objective: To evaluate the hepatoprotective and antioxidant potential of L. speciosa bark extract fraction against monosodium glutamate-induced liver toxicity. Methods: The phytochemical constituent of ethyl acetate fraction of L. speciosa bark extract (LSE) were identified by GC-MS analysis. The antioxidant activity of LSE were analyzed with in-vitro antioxidant assay and subjected to evaluate hepatoprotective activity against monosodium glutamate induced liver toxicity in rat. Results: LSE evaluated as rich in phenolics and flavonoid content along with potent hepatoprotective activity. GC-MS analysis of bioactive fraction exhibits Palmitic Acid, Octadecanoic acid, 5-methyluridine, catechine, epigallocatechin, and norgestrel as major biologically active phytocompounds. Oral administration of LSE (100 and 200 mg/kg.) declined the elevated levels of the biochemical marker as well as interleukins while enhanced the enzymatic antioxidant activity and reduced the increased level of stress marker (MDA) in monosodium glutamate-induced rats. It also restored the altered expression level of proapoptotic genes, but there is no significant change in the expression level of the anti-apoptotic gene. LSE improved histopathology of the liver through the improvement of hepatocellular architecture, inflammation, and attenuation of vascular and cellular degeneration. Conclusion: The bioactive fraction of L. speciosa bark was found to exhibit strong antioxidant and hepatoprotection in monosodium glutamate induced liver toxicity in rats.

VL - 12 IS - 6s ER -