@article {1077, title = {Activity of Kincung Flowers (Etlingera Elatior (Jack) R.M.Sm.) on Total Leukocytes and Percentage of Leukocytes in Allergic Male White Mice}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {February 2020}, pages = {44-51}, type = {Original Article}, chapter = {44}, abstract = {

Introduction: Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) is a native herbal plant in Southeast Asia that traditionally used to many diseases, especially in Indonesia. Aim: This study was conducted to determine the activity of kincung (Etlingera elatior (Jack) R.M.Sm.) on the total number of leukocytes and differential leukocyte cells in allergic mice. Material and Methods: The semi-solid extract of Kincung flower (Etlingera elatior (Jack) R.M.Sm.) was made by the maceration method using 70\% ethanol solvent. The animals used were 20 male white mice that have allergies of skin that treated with 20\% albumen antigens given on the first day 0.2 mL/20 g intraperitoneally, then on the seventh day are given antigens with the same dose subcutaneously. Allergic mice indicated by redness at the injection site. It divided into four groups: the negative control group and three dose groups (100; 300; and 1000 mg/kg). On the seventh day after administration of the extract, observed the value of total leukocytes and differential leukocyte cells in mice. Results: The results after administration of extracts in 3 dose groups (100; 300; and 1000 mg / kg) and the negative control group showed sequentially the total number of leukocytes was: 3.95; 4.73; 6.01; and 3.6 x103/μL and the percentage of leukocytes consisting of lymphocytes: 67.6\%; 62.0\%; 56.8\% and 70.0\%, neutrophils: 22.4\%; 29.2\%; 36.8\% and 20.0\%, eosinophils: 6.4\%; 5.8\%, 4.2\% and 6.6\%, monocytes: 3.6\%; 3.0\%, 2.2\% and 3.4\%, and basophils: 1.8\%; 1.4; 0.8\% and 2.0\%. It concluded that kincung flowers could increase total leukocytes significantly (p\<0.05), decrease lymphocytes, eosinophils, basophils significantly (p\<0.05), increase neutrophils significantly (p\<0.05), and reduce monocytes insignificantly (p\>0.05). Conclusion: Kincung flowers (Etlingera Elatior (Jack) R.M.Sm.) can be used as an immunomodulator and decreasing the percentage of basophil cells, and eosinophils can used as an anti-allergic drug.

}, keywords = {Allergies, Etlingera elatior (Jack) R.M.Sm, Kincung Flower, Leukocyte Percentage, Mice, Total Leukocytes}, doi = {10.5530/pj.2020.12.8}, author = {Yufri Aldi and Elidahanum Husni and Relin Yesika} }