@article {1293, title = {Topical Anti-Inflammatory Activity of Bromelain}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {November 2020}, pages = {1586-1593}, type = {Original Article}, chapter = {1586}, abstract = {

Introduction: Bromelain is a proteolytic enzyme found in pineapple plants. Aim: This study conducted to determine the activity of bromelain enzyme as an anti-inflammatory using the Granuloma Pouch method. Methods: The experimental animals were divided into five groups, namely the positive control group, the bromelain concentration group of 0.1\%; 0.5\%; 1\%, and the comparison group. Experimental animals induced carrageenan 2\% subcutaneously. The dosage form is given topically for 2, 4, and 6 days. The observation was made by measuring the volume of edema, the total number, and the percentage of leukocyte cells on days 2, 4, and 6. Results: The observation results of a positive control group, bromelain concentration 0.1\%, 0.5\%, 1\%, and the comparators, there was a significant decrease for the volume of exudate on days 2, 4, and 6 (p\<0.05). The average total number of leukocytes also decreased significantly (p\<0.05) in the positive control, the bromelain, and comparison group in day 2, 4, and 6. At the same time, the mean leucocyte percentage had no effect (p\>0.05). Conclusion: From the results of the study, it was concluded that the bromelain enzyme at concentration 0.1\%, 0.5\%, and 1\% have an anti-inflammatory effect by suppressing the volume of exudate, and the total number of leucocyte.

}, keywords = {Anti-inflammatory, Bromelain, Exudate, Gel, Granuloma, Leukocyte}, doi = {10.5530/pj.2020.12.217}, author = {Elsa Badriyya and Salman and Amalia Refina Pratiwi and Dwisari Dillasamola and Yufri Aldi and Elidahanum Husni} }