@article {1422, title = {Antiviral Activity of an Extract from Leaves of the Tropical Plant Cynometra cauliflora}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {752-757}, type = {Research Article}, chapter = {752}, abstract = {

Background: Cynometra cauliflora is a species of tree in the family Fabaceae and has been used in folk medicinal preparation. Objectives: In this study, Cynometra cauliflora methanolic leaves extract was tested against clinical isolate herpes simplex virus type-1 (HSV-1). Materials and Methods: The leaves of C. cauliflora plant was extracted using methanol extraction method. Cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide (MTT) assay. Plaque reduction assays were carried out to evaluate the antiviral activity of C. cauliflora extract against HSV-1. These include post-treatment, pre-treatment and virucidal assays. Results: The value of cytotoxic concentration, CC50 of C. cauliflora extract was 36 mg/ mL. High antiviral activity was observed in post-treatment. C. cauliflora extract treatment was found to not interfere directly to infectious particle and confer mild protection when given as prophylaxis. Conclusion: This study provides important novel insights on the phytomedicinal properties of C. cauliflora extracts on HSV-1.

}, keywords = {(3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide); virucidal., Cynometra cauliflora, Herpes simplex virus type 1, plaque reduction assay}, doi = {10.5530/pj.2021.13.96}, author = {Noor Zarina Abd Wahab and Aziah Azizul and Norhidayah Badya and Nazlina Ibrahim} }