@article {1635, title = {Total Phenol Content and Gastric Anti-Ulcer Activity of Hydroalcoholic Extract of Persea caerulea (Ruiz \& Pav.) Mez. Bark}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1072-1078}, type = {Original Article}, chapter = {1072}, abstract = {

Objective: Determine the content of total phenols and evaluate the gastroprotective effect of the extract of Persea caerulea (Ruiz \& Pav.) Mez. in mice with induced gastric ulcer. Material and Methods: The bark of Persea caerulea was macerated in 70\% ethanol and the phenol content was determined using the Folin-Ciocalteu method. The female Mus musculus Balb/c specimens were distributed in the following groups: White Control Group, without indomethacin dosing; Negative Control Group, dosing with indomethacin; Positive Control Group treated with ranitidine at a dose of 50 mg/kg; Groups P. caerulea treated with extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Gastric ulcer was induced with indomethacin orally at a dose of 50 mg/kg, the procedure was repeated 12 hours later; Gastroprotective treatment was administered 60 minutes after each dose of indomethacin, 6 hours after the last dose, sodium pentobarbital was euthanized and the stomach was resected to determine ulceration using the Marhuenda Scale. Results: Higher percentages of gastric ulcer inhibition were obtained in the P. caerulea 100 mg/kg (80\%) and P. caerulea 200 mg/kg (85.71\%) groups. Conclusions: Extract of Persea caerulea (Ruiz \& Pav.) Mez., At doses of 100 and 200 mg/kg of body weight, has a gastric antiulcerative effect which is related to its content of total polyphenols.

}, keywords = {Gastric ulcer, Indomethacin, Mice}, doi = {10.5530/pj.2021.13.139}, author = {Abhel A. Calder{\'o}n-Pe{\~n}a and Cinthya L. Aspajo-Villalaz and Carmen R. Silva-Correa and V{\'\i}ctor E. Villarreal-La Torre and Mar{\'\i}a V Gonz{\'a}lez-Blas and Orlando E Pretel-Sevillano and Marco L Salazar-Castillo and Maricielo Vaella-Alarc{\'o}n and Franco Huaccha-C{\'a}ceres and Jonatam Le{\'o}n-Soto and Whendy Alaya-Davir{\'a}n and Anabel D. Gonz{\'a}lez-Siccha and William Antonio Sag{\'a}stegui-Guarniz and Luz M. Guerrero-Espino and Julio Hilario-Vargas} }