@article {1640, title = {Myocardium Neutrophil Infiltration in Rat Model with Acute Myocardial Infarction Treated by Ramipril}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1116-1121}, type = {Original Article}, chapter = {1116}, abstract = {

Introduction: Acute myocardial infarction (AMI) is a cardiovascular disease that attacks myocardial cells due to long-standing ischemia. In AMI there is neutrophil infiltration associated with the prognosis of the disease. One of the initial therapies for AMI is ACE inhibitors. Objective: To determine myocardial neutrophil infiltration In rat model with acute myocardial infarction which is given ramipril as an Ace inhibitor. Method: This research is an experimental study using the Post Test Only Control Group study design. This study used 24 experimental rats which were divided into 3 treatment groups. Data were analyzed using the One Way ANOVA test and the Least Significant Differences test. Results: The results obtained were the mean number of neutrophils in the K(-) group was 1.83, the K(+) group was 22.67, and the successive treatment group was 4,17. Significant differences were obtained between the K(+) group and the treatment group where the p value was 0.001 (p \<0.05). Conclusion: There is an effect of 4 mg/kg BW ACE Inhibitor ramipril and on the number of myocardial neutrophils of rats with AMI.

}, keywords = {ACE inhibitors, Acute Myocardial Infarction (AMI), Neutrophils, Ramipril}, doi = {10.5530/pj.2021.13.144}, author = {Biomechy Oktomalioputri and Meutia Savitri and Dwisari Dillasamola and Noverial} }