@article {1713, title = {Antidiabetic Activity of the Leaf Extract of Eurycoma Longifolia Jack. in Streptozotocin-Nicotinamide Induced Diabetic Model}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {December 2021}, pages = {1582-1588}, type = {Original Article}, chapter = {1582}, abstract = {

Background: One of the medication attempts in diabetes mellitus is by utilising plants that are potent as an antioxidant. Eurycoma longifolia Jack. known as {\textquotedblleft}Longjack{\textquotedblright} in English, is a medicinal plant and reportedly effective as an antioxidant. Objectives: This study was aimed to examine the antidiabetic effectiveness of ethanol extract of longjack leaf in diabetes mellitus rats. Methods: This study used the total of 24 male white rats which were grouped into four. The normal and the negative control groups were administrated with CMC-Na 0.5\% dose 2 ml/200 g body weight; one group was administrated with ethanol extract of longjack leaf dose 176.4 mg/200 g body weight; and the positive control group was administrated with glibenclamide dose 0.09 mg/200 g body weight. Before the extract administration, all of the experimental animals were prior induced into diabetic condition with streptozotocin-nicotinamide. Results: The levels of blood glucose and malondialdehyde in rats after the 14-day extract treatments were 78.73 mg/dl and 1.13 nmol/ml, respectively in the normal control group; 285.84 mg/dl and 10.03 nmol/ml were in the negative control group; 156.77 mg/dl and 3.86 nmol/ml in the group with the administration of ethanol extract of longjack leaf; and 148.63 mg/dl dan 3.64 nmol/ml in the group of glibenclamide administration (p\<0.05). The reduction of blood glucose and malondialdehyde levels in the groups of ethanol extract administration of longjack leaf dose 176.4 mg/200 g body weight was similar to the glibenclamide administration dose 0.09 mg/200 g body weight. Conclusion: The ethanol extract of longjack leaf was effective as an antidiabetic.

}, keywords = {Blood glucose level, Diabetes mellitus, Eurycoma longifolia Jack. leaf.}, doi = {10.5530/pj.2021.13.203}, author = {Ruqiah Ganda Putri Panjaitan and Agus Astuti} }