@article {1913,
	title = {Correlation of the Presence of Non Structural-1 (NS1) Antigen Dengue Virus with Severity of Dengue Infection},
	journal = {Pharmacognosy Journal},
	volume = {14},
	year = {2022},
	month = {December 2022},
	pages = {813-816},
	type = {Research Article },
	chapter = {813},
	abstract = {<p class="rtejustify">Dengue is a major public health threat worldwide, affecting approximately 3 billion people. More than 100 countries in the world located in tropical and subtropical areas, there are at least 100 to 400 million people infected with the dengue virus which causes dengue hemorrhagic fever (DHF). Soluble Non Structural Protein (sNS1) DENV is a soluble NS1 protein that is secreted and found in the serum of patients during acute infection. Because of its presence early in infection, sNS1 is used as a diagnostic indicator of acute dengue infection. NS1 can directly activate platelets through TLR4 and can further increase platelet aggregation, endothelial cell adhesion, and phagocytosis by macrophages that can cause thrombocytopenia so that high sNS1 levels are associated with disease severity. From the results of the study showed p \&lt;0.05. This indicates that there is a correlation between the presence of NS1 and the severity of dengue infection.</p>
},
	keywords = {Dengue virus, NS1 antigen, Thrombocytopenia},
	doi = {10.5530/pj.2022.14.172},
	author = {Ichwan Baihaki and Beti Ernawati Dewi and Viol Dhea Kharisma and Ahmad Affan Ali Murtadlo and Muhammad Badrut Tamam and Devi Purnamasari and Nunuk Hariani Soekamto and ANM Ansori and Kuswati and Riso Sari Mandeli and Kawther Ameen Muhammed Saeed Aledresi and Nur Farhana Mohd Yusof and Vikash Jakhmola and Maksim Rebezov and Pavel Burkov and Marina Derkho and Pavel Scherbakov and Rahadian Zainul and Muhammad Raffi Ghifari and Asmi Citra Malina AR Tasakka and Tengku Siti Hajar Haryuna}
}
