@article {2338, title = {Evaluation of Antiurolithiatic Potential of Methanolic Stem Extract of Spermacocce articularis L.f.: An In vitro and In vivo Approach}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {August 2024}, pages = {770-778}, type = {Original Article}, chapter = {770}, abstract = {

Context: Polygenic urolithiasis has a complicated etiology and even more varied therapeutic outcomes. Spermacoce articularis L.f. has been used historically for stone treatments in several traditional medical systems. Aim: The current study aimed to investigate the in vitro and in vivo anti-urolithiatic potential of Spermacoce articularis Stem Extract (SASE). Methods: In vitro antiurolithiatic potential on the CaOx crystallization was evaluated using nucleation and aggregation assays. In vivo, activity was assessed on renal calculi-induced Wistar rats by polyethylene glycol (0.75\%) in drinking water for 14 days. SASE and cystone with two experimental doses (250 and 500 mg/kg, p.o.) were dispensed for ten days. Various biochemical parameters were assessed in the kidneys{\textquoteright} serum, urine, and histological sections. In addition, SASE inhibited CaOx crystallization by reducing the density of crystals, triggering the breakdown of CaOx crystals, and hindering their growth. Cystone demonstrated comparable outcomes. Results: Upon treatment with SASE, urinary, serum, kidney homogenates, and antioxidants were significantly improved (p\<0.05) to normal levels. The histopathology of the kidney section showed no damaged cells of SASE treated and Cystone treated compared with that of control animals. Conclusion: This research validates the traditional idea and suggests that SASE is advantageous in preventing the growth of urinary stones.

}, keywords = {calcium oxalate, In vivo, Polyethylene glycol, Spermacoce articularis, Urolithiasis}, doi = {10.5530/pj.2024.16.128}, author = {S Gopika and MK Nisha and E Gaayathiri Devi and A Raja Rajeswari and R Vasandhlakshmi} }