@article {2539, title = {Acute Oral Toxicity Evaluation of Hydroalcoholic Extract of Salvia Officinalis Roots in Wistar Rats as per OECD 423 TG}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {September 2025}, pages = {577-582}, type = {Original Article}, chapter = {577}, abstract = {

Background: In this study, we assessed the hydroalcoholic root extract of Salvia officinalis oral acute toxicity investigation using an animal model. Methods: The investigation of acute oral toxicity was conducted using OECD 423 guidelines. The Institutional Animal Ethics Committee approved the study (IAEC). A single oral dose of Salvia officinalis hydroalcoholic root extract (800, 1600, and 3200 mg/kg) was administered, and the subjects were monitored for 14 days. Animals were sacrificed on the fifteenth day, and body weight, haematological, and serum hepatic biochemical parameters were assessed and compared to the standard group. Results:Groups treated with Salvia officinalis showed no mortality or discernible alterations. The findings show that Wistar rats did not experience appreciable harmful effects from administering hydroalcoholic root extract from the Salvia officinalis plant. Conclusions: The extract can be utilized safely for therapeutic use in pharmaceutical formulations.

}, keywords = {Acute toxicity, Haematology, heart, Kidney, Liver, Salvia officinalis}, doi = {10.5530/pj.2025.17.71}, author = {Ranjini HS and Kadmad Abdul Hameed Mohamed Azar and S Fayazul Haq and Prashanthkumar Goudappala and Vinodakumar HR and Akash A} }