@article {2582, title = {Efficacy of Standardized Withania Somnifera as Neuro Agent in Tension-Type Headache: A Comparative Trial of Data in Transit}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {December 2025}, pages = {378-385}, type = {Original Article}, chapter = {378}, abstract = {

Background: To evaluate the role of withania somnifera as a neuro-psychiatric agent in the treatment of Tension-Type Headache (TTH), there is a need to substantiate the therapy using solid therapeutic evidence. Although using traditional medicine has a great potential, it is difficult to demonstrate the efficacy of a particular phytochemical composition regarding the frequency of and physiological stress markers of the chronic Tension-Type Headache in standardized research. Objective: The purpose of the study is to assess the therapeutic efficacy of a standardized Withania somnifera extract in reducing the frequency of and physiological stress markers of the chronic Tension-Type Headache. Methods: We used the study as a double-blind and randomized controlled trial (RCT). The subjects were randomly selected to be given a standardized extract of the root of W. somnifera, that has been titrated to contain 5 percent withanolides, or a placebo dose of 60 days. The paper ensured a rigorous "molecular chain of custody" with a batch of withanolides linked in clinical outcome reported where the mean frequency of headaches in the treatment group reduced by 42\% (p [Less than] 0.005). Results: Clinical outcome showed that there was a significant decline in the frequency of headaches in the treatment group by 42\% (p [Less than] 0.005). Moreover, the Ashwagandha group was showing a significant drop in salivary cortisol levels, which means that there was a decrease in the level of physiological stress response to chronic TTH. Conclusion: Standardized natural products should be integrated into clinical trials as it is the most beneficial to the development of sustainable pharmacognosy. This experiment can offer an unambiguous evidence base, a clear and reproducible basis of evidence regarding the use of Ashwagandha in the current neurological practice by showing the clear efficacy in reducing the frequency of Tension-Type Headaches and biological stress markers.

}, keywords = {Biomarker Integrity, Phytochemical Standardization, Sustainable Research Framework, Tension-Type Headache, Withania somnifera}, doi = {10.5530/pj.2025.17s.109}, author = {Ashwani Kumar and Prikshat Kumar Angra and Suresh Chandra Akula and Pritpal Singh and Anuj Sharma and Anup Sharma} }