@article {464, title = {Angiotensin-Converting Enzyme Inhibition of Fractions from Eleusine indica Leaf Extracts}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {25-28}, type = {Original Article}, chapter = {25}, abstract = {

Solvent fractions and decoction of Eleusine indica leaves were tested for their ability to inhibit angiotensin-converting enzyme (ACE), an important component of the Renin-Angiotensin- Aldosterone System which is a critical regulator of arterial blood pressure. The ACE inhibitory activity of each fraction was measured by employing a colorimetric assay based on the hydrolysis of histidyl-hippuryl-leucine (HHL) by ACE. Preliminary assay results revealed that the ethyl acetate fraction exhibited the highest antihypertensive activity with a percent inhibition of 51.51\%. This fraction was considered for further isolation using a bioassay-guided fractionation scheme.

}, keywords = {Bioactive extracts, High-blood pressure, Hypertension, Medicinal, Plant extracts}, doi = {10.5530/pj.2018.1.5}, url = {http://fulltxt.org/article/360}, author = {Jasmin T Tutor and Christine L Chichioco-Hernandez} }