@article {451, title = {Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {November 2017}, pages = {s93-s98}, type = {Original Article}, chapter = {s93}, abstract = {

Background: The plants of genus Cordia has been used in traditional medicine for many diseases from history. Cordia obliqua Willd. is also a medicinally important plant and it has been proved by modern scientific research. Objective: This study is aimed to formulate and characterize a topical gel from Cordia obliqua leaf methanol extract and evaluate its effect on carrageenan induced rat paw edema. Materials and Methods: The methanol extract was prepared by successive solvent extraction using soxhlet apparatus. Topical gel was designed to prepare by Dispersion method using Carbopol 940 as polymer. The various gel characteristics was studied by standard procedures like Homogeneity, grittiness, extrudability, drug content, spread ability and in-vitro diffusion study. The anti-inflammatory potential of gel was evaluated by Carrageenan induced rat paw edema method in comparison with standard Diclofenac Sodium gel 1\% on Albino rats. Results: The herbal gel was found homogeneous with good extrudability, no grittiness, pH 6.79 and drug content 93.167\%. The anti-inflammatory activity of herbal gel was found comparable with standard Diclofenac Sodium gel and has shown 82.71\% edema inhibition after 4 h of treatment. Conclusion: Cordia obliqua gel was found suitable as a standard topical gel formulation and it can be used safely for treatment of edema.

}, keywords = {Carbopol 940, Carrageenan induced edema, Cordia, in-vitro diffusion, Topical gel}, doi = {10.5530/pj.2017.6s.163}, url = {http://fulltxt.org/article/388}, author = {Richa Gupta and Ghanshyam Das Gupta} } @article {419, title = {Toxicity Assessment and Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Activities on Cordia obliqua Leaf Methanol Extract}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {856-861}, type = {Original Article}, chapter = {856}, abstract = {

Background: Cordia obliqua Willd. Plant belongs to genus Cordia and family Boraginaceae. Commonly it is known as Clammy Cherry and in Hindi Lasora. Earlier very few researches were carried out to explore its medicinal importance as compared with other Cordia species. Objective: To determine maximum safe dose and explore analgesic, anti-inflammatory and antipyretic activities of Cordia obliqua leaf methanol extract. Materials and Methods: As per our previous study report, the leaf methanol extract is rich in phyto-constituents and has good antioxidant effect; so only methanol extract was studied here. The maximum safe dose of methanol extract was found by acute oral toxicity study according to OECD guidelines 423. For analgesic effect, hot plate and tail flick method, for anti-inflammatory, Carageenan induced rat paw edema and for antipyretic study, yeast induced pyrexia method were used. Results: The extract dose up to 2000mg/Kg was found safe with no any side effects. Three dose levels were tested for all activities. The medium (250 mg/Kg) and high (500 mg/Kg) dose of methanol extract was found effective in all activities when compared with standard. The result for antipyretic activity was found better than other activities. Conclusion: It can be concluded that Cordia obliqua leaf is safe and effective drug for relief of pain, fever and inflammation.

}, keywords = {Carageenan induced edema, Clammy Cherry, Hot plate, Tail flick, Yeast induced pyrexia.}, doi = {10.5530/pj.2017.6.134}, url = {http://fulltxt.org/article/187}, author = {Richa Gupta and Ghanshyam Das Gupta} }