@article {435, title = {Neuroprotective Effect of Pedalium murex Linn. Leaf against Lipopolysaccharide Induced Behavioural Disorders in Rats}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {957-962}, type = {Original Article}, chapter = {957}, abstract = {

Introduction: Effective treatment is necessary to minimize the neuronal damage and oxidative stress. Traditional medicines offer potent pharmacological activity with minimal side effects compared to synthetic drugs to treat such chronic disorders. There is no renowned remedy for arrest or rescuing infection or inflammation-induced brain damage. The present study was aimed to evaluate the neuroprotective effect of ethanol extract of Pedalium murex Linn. (EEPM) leaves against lipopolysaccharide (LPS)-induced endotoxemia. Methods: Neurodegeneration was induced in rats with a single intraperitoneal injection of LPS (1 mg/kg). The induced endotoxemia constantly linked with battery of behavioural tests viz., choice reaction time task (CRT), 8-arm radial maze (RAM) and water maze test (WMT). At the end of the study, rats were sacrificed, brain hippocampal region was removed and biochemical parameters were measured. Results: In WMT swimming length (cm) was increased in LPS-treated rats when compared to control animals, the swimming length (EEPM; 400 mg/kg) was found to be significant; in RAM, different doses of EEPM at 100, 200 and 400 mg/kg decreased the number of errors in entry 4.00\±0.36, 4.16\±0.16and 3.33\±2.79 respectively when compared with control animals (2.66\± 0.21). EEPM at 400 mg/kg showed significant activity, in CRT apparatus increased incorrect lever pressing was observed in LPS-treated rats when compared to control animals. Incorrect lever pressing was minimized by EEPM at 400 mg/kg (43.5\±2.40). Conclusions: Our results showed that EEPM is a hopeful aspirant for hindrance of infection and inflammation induced brain damage by LPS.

}, keywords = {Behavioural studies, Learning, Memory, Neuroprotective, Oxidative stress, Pedalium murex.}, doi = {10.5530/pj.2017.6.150}, author = {Swaminathan Gomathi and Rajagopal Shanmuga Sundaram and Vellaichamy Muthupandi Annapandian and Manickam Vijayabaskaran} } @article {432, title = {Phytochemical Evaluation and Chromatographic Fingerprint Analysis on Flavonoids Compounds in Leucas aspera (Willd.) Link Leaf by HPTLC}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {942-946}, type = {Original Article}, chapter = {942}, abstract = {

Introduction: Leucas aspera is one of the important medicinal plants in Indian medical system and it belongs to Lamiaceae family. Leucas aspera (Willd) Link (L. aspera) belongs to Leucas genus, widely distributed throughout India. L. aspera has many vernacular names and is commonly known as Thumbai. Flavonoid is a phenolic compound which is widely distributed in the plants and responsible for many biological activities. Preliminary phytochemical analysis gives a broad idea to the researchers for their further research. Methods: In this present study, we did a preliminary phytochemical screening, quantitative estimation of total flavonoids and fingerprinting profile of flavonoids compounds using five different solvent extracts obtained from leaves of L. aspera. Results: Preliminary phytochemical screening confirmed the presence of flavonoid compounds in L. aspera. Higher concentration of total flavonoid compounds was noted in ethanol extract compared to petroleum ether, chloroform, isopropyl alcohol and ethyl acetate extracts. A densitometric high performance thin layer chromatography (HPTLC) study showed more number of flavonoid compounds are present in ethanol extract compared to other solvents. Conclusions: Results of this study revealed, L. aspera leaf is a rich source of flavonoid content and it can be used to alleviate many chronic illness and various diseases. This study results warrants for further isolation, identification and characterization of active principle which is responsible for the biological activity.

}, keywords = {Chromatographic, Fingerprinting, Flavonoids, HPTLC, Leucas aspera.}, doi = {10.5530/pj.2017.6.147}, url = {http://fulltxt.org/article/200}, author = {Vellaichamy Muthupandi Annapandian and Rajagopal Shanmuga Sundaram and Swaminathan Gomathi} }