@article {908, title = {Free Radicals Scavenging Activity and Oxidative DNA Damage Protecting Property of Methanol Extract from Honeycrisp Apple}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {July 2019}, pages = {694-698}, type = {Original Article}, chapter = {694}, abstract = {

Objectives: This research reports the qualitative phytochemical constituents and considers the in vitro free radicals scavenging activities based on DPPH and nitric oxide assays and oxidative DNA damage protection activity of methanol extract from Honeycrisp apple. The foremost interest for this research was to use standard measures to determine nitric oxide scavenging activity, DPPH-scavenging activity and DNA damage protecting activity to assess the antioxidant potential of methanol extract from the apple. Materials and Methods: Concentrations of apple extracts with the intervals 20 μg/ml to 100 μmg/ml were prepared and mixed with suitable volumes of reagents and the corresponding absorbances read at the respective wavelength. Results: The outcomes of this research specify that methanol extract of Honeycrisp apple contain multiple phytochemical compounds that can expertly shield the body against oxidative stress caused by free radicals and might then be used as a source of potent natural antioxidant compounds. The IC50 values of methanol extract from Honeycrisp apple varied from 10.30 to 36.29 μg/ml which indicates the high radical scavenging activity of the sample. Conclusion: The DNA damage defensive potential of the extracts was also revealed, which could be used in cancer inhibition.

}, keywords = {DNA damaging, DPPH, Free Radicals, Honeycrisp apple, Nitric oxide, Phytochemicals}, doi = {10.5530/pj.2019.11.110}, author = {Williams Kweku Darkwah and Matthew Nkoom} } @article {703, title = {Phytochemical Constituents, Total Saponins, Alkaloids, Flavonoids and Vitamin C Contents of Ethanol Extracts of five Solanum torvum Fruits}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {August 2018}, pages = {946-950}, type = {Original Article}, chapter = {946}, abstract = {

Introduction: Phytochemicals are frequently used in chemotherapeutic treatment or may be used as chemo preventive agents with chemoprevention. The study report the quantification of phytochemical constituents and vitamin C contents from ethanol extracts of Solanum torvum fruits. Method: The main objective for this research was to use standard procedures to determine phytochemical and vitamin C content. Results: The estimated alkaloids found in mature fruits were 6.32 \± 0.12 mg/g and 16.94 \± 2.3 mg/g in the immature fruits. Total saponins in mature and immature fruits were 8.60 \± 2.6 mg/g and 16.90 \± 9.4 mg/g respectively. Total flavonoids in mature and immature fruits were 21.14 \± 4.4 mg/g and 14.24 \± 1.8 mg/g respectively. Also vitamin C contents were 11.79 \± 2.0 mg/g in mature fruits and 8.70 \± 0.26 mg/g in immature fruits. With the exception of alkaloids whose difference in the mature and immature was significant, other differences obtained were not significant. Conclusion: The study showed that the extracts contain diversity of phytochemicals in appreciable amount that can expertly keep the body against oxidative stress triggered by free radicals and therefore be used as a source of potent natural products.

}, keywords = {Alkaloids, Ethanol Extract, Flavonoids, Phytochemicals, Saponins, Solanum torvum fruits}, doi = {10.5530/pj.2018.5.160}, author = {Desmond Ato Koomson and Benjamin Danso Kwakye and Williams Kweku Darkwah and Bismark Odum and Mabel Asante and Gideon Aidoo} }