@article {1748, title = {Imperata cylindrica and Moringa oleifera: Antithrombotic Effect on Pulmonary Thromboembolism in Mice}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {February 2022}, pages = {148-153}, type = {Research Article}, chapter = {148}, abstract = {

Background: Imperata cylindrica and Moringa oleifera have been used widely as a traditional medicine to treat various diseases. These plants also have some compounds that are proven in vitro for their action to reduce platelet aggregation which has a major role in thrombosis pathogenesis. Objective: This study aimed to evaluate the effect of ethanolic extracts from I. cylindrica and M. oleifera as an antithrombotic agent in mice. Methods: The effects of I. cylindrica and M. oleifera on the pulmonary thrombosis in vivo and bleeding time parameters were examined. The two extracts were given orally for seven days prior to thrombosis induction. Survival rate was observed by the calculation of dead or paralysed mice and bleeding time was observed on amputated mice tails. Results: I. cylindrica and M. oleifera prevented paralyse and death caused by collagen-epinephrine induced pulmonary thrombosis in mice after 7 days pre-treatment in dose-dependent manner. The mouse tail bleeding time was significantly prolonged by administration of the extract, where I. cylindrica showed the most potent. Conclusion: These results suggest that the extract of I. cylindrica and M. oleifera have a potential activity as an antithrombotic agent in vivo.

Key words: Antithrombotic, Imperata cylindrica, Moringa oleifera, Survival rate, Pulmonary thromboembolism, Bleeding time.

}, doi = {10.5530/pj.2022.14.20}, author = {Fadlina Chany Saputri and Arini Andriani and Nuriza Ulul Azmi} } @article {861, title = {Antithrombotic Effect of Mucuna pruriens L. and Coriandrum sativum}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {413-417}, type = {Original Article}, chapter = {213}, abstract = {

Background: Mucuna pruriens (MP) L. and Coriandrum sativum (CS) have been found for in vitro antithrombotic activity. However, the in vivo studies for both plants have not been discovered yet. Objective: The objective of the study is to prove the efficacy of MP L. and CS by conducting in vivo antithrombotic activity test with bleeding time and survival rate as the parameters. Materials and Methods: MP and CS extracts with three different doses were given orally to the experimental animals for 7 days. Aspirin was used as a positive control. The bleeding time was observed on mice tail that had been cut, and the survival rate was determined by inducing thrombosis with collagen{\textendash}epinephrine injection. Results: Seven-day treatment of plant extracts significantly prolonged the bleeding time of the treated group compared to the normal control group. The result demonstrated the increasing number of survived animals in the treated group compared to the negative control group. Conclusion: Both extracts had shown antithrombotic activity by significantly prolonged the bleeding time and increased the survival rate.

}, keywords = {Antithrombotic, Bleeding time, collagen, Coriandrum sativum, Mucuna pruriens L, Survival rate}, doi = {10.5530/pj.2019.11.64}, author = {Nuriza Ulul Azmi and Astari Rachma Nityasa and Fadlina Chany Saputri} }