@article {1614, title = {Hypoglycemic and Antianemia Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaves in Rats}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {924-932}, type = {Research Article}, chapter = {924}, abstract = {

Background: Beneficial effect of katuk (Sauropus androgynus L Merr) leaves (CSA) as one of medicinal plant in Indonesian jamu may potential to cure diabetes mellitus (DM) and iron deficiency anemia (IDA) as well as its well-known effect to increase breast milk production. Objectives: This study was aiming to explore the hypoglycemic effects of CSA in streptozotocininduced DM rats (STZ) and antianemia effects in IDA rats (FeD). Material and Methods: STZ male Wistar rats were treated with CSA, commercial chlorophyll (Chln) and glibencamide. Blood glucose levels and histological changes of liver, kidney and pancreas were analyzed after 14 days treatment. At separate experiment, FeD female Wistar rats were treated with CSA and Chln. The treatment was performed orally at the 1st - 20th day of pregnancy. Levels of Hb, Fe and ferritin blood serum, number and body weight of the offspring were analyzed on 21st day (post-partum). Results: Treatment of CSA for 14 days to diabetic animals demonstrated the hypoglycemic effect, however the histological analysis suggested that the scores of liver, kidney and pancreas were higher than that in the normal group. Moreover, CSA exerted a significant restorative effect by returning the levels of hemoglobin, serum iron, and serum ferritin. A fetus analysis suggested that the fetus body weight of in the CSA and Chln groups was similar to that in the normal group. Conclusion: CSA treatment are potential as a new herbal supplement to cure DM and IDA. However, the safety dose should be considered to prevent the toxicity.

}, keywords = {Antioxidants, Chlorophyll, Diabetes mellitus (DM), Iron deficiency anemia (IDA), Sauropus androgynus (L) Merr}, doi = {10.5530/pj.2021.13.119}, author = {Suparmi Suparmi and Minidian Fasitasari and Martanto Martosupono and Jubhar Christian Mangimbulude} } @article {1087, title = {Iron-Folate Supplementation during Pregnancy for Prevent Oxidative Stress in Pregnant Rats: Level of MDA, Creatinine, Glucose, Erythrocite, Blood Pressure, Body Weight and Number of Offspring}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {February 2020}, pages = {186-191}, type = {Research Article}, chapter = {186}, abstract = {

Background: Iron and folic acid deficiency during pregnancy can increase oxidative stress and result in impaired intra-uterine growth, abortion and preeclampsia. Folate is trace nutrient that influent for essential role for epigenetic mechanism cues into changes in gene expression and had impact health development. This study aimed to determine the effect of several doses of iron and folate supplementation on level of: MDA, glucose, creatinine, maternal body weight and number and birth weight of offspring. Methods: This research was conducted in the laboratory of the Center for Food and Nutrition Studies, Gadjah Mada University Yogyakarta. Experimental research with posttest only control group design with a number of samples: 20 pregnant rats, divided randomly into 4 groups. The control group (C) was given standard feed (AIN-93G), KI: added iron 1,8 mg/200gBW and folic acid 0,0023mg/200gBW, KII: added iron 3,6 mg/200gBB and folic acid 0,0045 mg/200gBW, KIII : added iron 5,4mg/200gBW and folic acid 0,0068 mg/200gBW. Duration of treatment 20 days. Measurement of body weight, blood pressure and then taken blood samples at the 21st day for examination of MDA, glucose, creatinine, erythrocyte level. Sectio caesarean to performed the number and body weight of offspring. Data obtained were analyzed using one way Anova followed by Post hoc LSD. Results: there are significant different (p \<0.001). on level of : MDA, glucose, creatinine, maternal body weight, average number and fetal weight of offspring between treatment group compare to control group. Conclusion: Iron and folate suplementation during pregnancy can decreased level of oxidative stress and better pregnant outcome.

}, keywords = {Folic acid, Iron, MDA, Oxidative stress, Pregnancy}, doi = {10.5530/pj.2020.12.28}, author = {Joko Wahyuwibowo and Abdul Aziz and Eka Safitri and Minidian Fasitasari and Siti Thomas Zulaikhah} }