@article {1109, title = {Antioxidant and Antidiabetic Activities of Mempening (Lithocarpus bancanus) Leaves}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {March 2020}, pages = {328-334}, type = {Original Article}, chapter = {328}, abstract = {

Background: Lithocarpus bancanus or commonly called as mempening in Talang Mamak Tribe, Indonesia is a plant that is used as a traditional medicine. Objective: This study aim to evaluated antioxidant and antidiabetic activities of L. bancanus leaves extract. Material and Methods: The methanol extract was obtained by maceration of the leaves. The n-hexane, dichloromethane and ethyl acetate fractions were prepared by successive partition process of the methanol extract. Antioxidant activities were evaluated by various antioxidant assays, including DPPH (1,1-diphenyl-2-picrylhydrazyl), FRAP (ferric reducing antioxidant power), CUPRAC (cupric reducing antioxidant capacity), and ABTS (2,2{\textquoteright}-azonobis 3-ethylbenzothiazoline-6-sulfonic acid) method. Total phenolics were estimated based on the Folin{\textendash}Ciocalteu method, while, aluminum chloride methods were employed to estimate total flavonoids. Antidiabetic activies was determined by inhibiting the activity of α-glucosidase method. Results: antioxidant activity assay against DPPH radical as well as the total phenolic and flavonoid content of L. bancanus leaves showed that the methanol extract possessed IC50 value of 39.469 {\textpm} 0.273 μg/mL with total phenol and flavonoid were 11.426 {\textpm} 0.432 mg GAE/g dry weight sample and 15.423 {\textpm} 0.213 mg QE/g respectively. The FRAP, CUPRAC and ABTS values of methanol extract were 3494.302 {\textpm}0.456, 26665.501 {\textpm} 5.940 and 2857.977 {\textpm} 0.715 μM TE/g dry weight sample respectively. Antidiabetic activity of methanol extract with IC50 value of 30.565 {\textpm} 0.331 μg/mL. Conclusion: It could be concluded that leaves of L. bancanus have antioxidant and antidiabetic properties.

}, keywords = {Antidiabetic, Antioxidant, Lithocarpus bancanus, Talang Mamak Tribe}, doi = {10.5530/pj.2020.12.52}, author = {Muhammad Almurdani and Adel Zamri and Titania T Nugroho and Jasril Karim and Yum Eryanti and Rudi Hendra and Hilwan Yuda Teruna} }