@article {2029, title = {The Effect Supplementation of Microbiota Inoculant in the Early Laying Hens Feed on High Density Lipoprotein (HDL) and Low- Density Lipoprotein (LDL) in Egg Yolk}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {June 2023}, pages = {270-273}, type = {Original Article }, chapter = {270}, abstract = {

Laying hens (Gallus gallus) are one of the poultries kept for their eggs. Eggs produced by chickens are used as a source of human food that contains a lot of nutrition and is affordable. Eggs also contain high levels of cholesterol in the yolk, so if consumed in large quantities, they will pose a risk of disease. This study aims to determine the effect of giving probiotics in the early layer laying hen feed on the levels of high-density lipoprotein and low-density lipoprotein in egg yolks. This study has four treatments, namely P1 = control, P2 = feed + AGP, and P3 and P4 = feed + probiotics. The probiotic used is a combination of three bacteria, namely Lactobacillus plantarum, Lactobacillus acidophilus, and Bifidobacterium sp. The sample used in this study was egg yolk, which was collected in the last week of the study. Testing for HDL and LDL levels in egg yolks was carried out using the Quantitative Colorimetric/Fluorometric Determination of HDL and LDL/VLDL method. Testing HDL and LDL levels in this study showed that the administration of probiotics had an effect in the form of increasing HDL levels but did not have an effect in the form of a significant decrease in egg yolk LDL levels during the four-week treatment period in laying hens in the early layer phase, aged 18{\textendash}22 weeks. The best probiotic dose used among the three probiotic doses is 3 ml/kg of feed.

}, keywords = {High Density Lipoprotein, Laying hens, Low Density Lipoprotein, Probiotics.}, doi = {10.5530/pj.2023.15.73}, author = {Bodhi Agustono and Rini Apriliawati and Sunaryo Hadi Warsito and Maya Nurwartanti Yunita and Widya Paramita Lokapirnasari and Sri Hidanah and Emy Koestanti Sabdoningrum and Mohammad Anam Al-Arif and Mirni Lamid and Gandul Atik Yuliani and Shekhar Chhetri and Sarasati Windria} } @article {1193, title = {Capsaicin Bioactive in Cabai (Capsicum Annum L.) as Anticancer Through Inhibition of over Ekspresi Protein Target RAC-alpha serine/threonine-protein kinase (AKT1) and Mitogen-activated protein kinase 1 (MAPK1) on Hepatocyt Cell Mice (mus musculus)}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {June 2020}, pages = {911-915}, type = {Research Article}, chapter = {911}, abstract = {

Capsaicin is a secondary metabolite of the Chilean plant. In the pharmaceutical field in addition to relieving pain or pain, capsaicin is also known to have anticancer activity because it inhibits certain oncogenic proteins. Screening of components in Capsicum Annum L. against the target proteins AKT1 and MAPK1 is needed as an initial stage of drug discovery. Further screening of Capsaicin compounds for oncogenic proteins produced in Hepatocellular carcinoma (HCC) pathogenesis signaling. In silico data that have been obtained, Capsaicin in chili (Capsicum Annum L.) has a high affinity for MAPK1 and AKT1 receptor/protein targets with energy and potential activity score (Pa) 0.690 for preneoplastic treatment, 0.590 for apoptotic agonists, and 0.366 for antineoplastic activity. Statistical data using Kruskal Wallis obtained information that Capsaicin can inhibit the expression of AKT 1 and MAPK 1 on mice hepatocyte cells induced by AFB1 in vivo administration, therefore it can be a candidate for anticancer drugs.

}, keywords = {AKT1, Anticancer, Capsaicin, Hepatocellular carcinoma (HCC), MAPK1}, doi = {10.5530/pj.2020.12.129}, author = {Mohammad Sukmanadi and Sri Agus Sudjarwo and Mustofa Helmi Effendi and Pudji Srianto and Aulanni{\textquoteright}am and Rr Sri Pantja Madyawati and Mirni Lamid and Hani Plumeriastuti} }