@article {1364, title = {Hepatoprotective Activity of Cordia lutea Lam Flower Extracts Against Paracetamol-Induced Hepatotoxicity in Rats}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {309-316}, type = {Original Article}, chapter = {309}, abstract = {

Background: Paracetamol or acetaminophen overdose leads to hepatotoxicity. This study evaluates the effect of Cordia lutea extract on paracetamol-induced hepatotoxicity in rats. Methods: Three different doses of dry fluid extract of C. lutea (200, 400 and 600 mg / Kg) were evaluated and compared with Silymarin 200 mg / Kg. Biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), direct bilirubin, indirect bilirubin, total bilirubin, albumin, globulin and total proteins were evaluated, and histopathological changes in the liver were studied and evaluated. Results: C. lutea reduced the levels of ALT, AST, ALP and increases proteins significantly, although the reduction of bilirubin was not significant, the extract at 400 mg / Kg reduced the levels better than the extract at 600 mg / Kg. The histopathological evaluation suggested that C. lutea extract reduced paracetamol-induced liver necrosis. Conclusions: The extract of C. lutea has a marked hepatoprotective effect, significantly reducing the levels of ALT, AST and ALP, in addition to increasing the levels of albumin, globulin and total proteins, in Rattus norvegicus var. albinus. C. lutea extract is an excellent candidate for use in paracetamol-induced liver diseases.

}, keywords = {Acetaminophen, Biochemical parameters, Cordia lutea, Hepatoprotection, Histopathology, Paracetamol}, doi = {10.5530/pj.2021.13.40}, author = {Ruiz-Reyes SG and Villarreal-La Torre V{\'\i}ctor E and Silva-Correa Carmen R and Sag{\'a}stegui Guarniz William Antonio and Cruzado-Razco Jos{\'e} L and Gamarra-S{\'a}nchez C{\'e}sar D and Venegas Casanova Edmundo A and Miranda-Leyva Manuel and Valdiviezo Campos Juan Ernesto and Cuellar-Cuellar Armando} } @article {1229, title = {Hepatoprotective and Nephroprotective Activity of Artemisia absinthium L. on Diclofenac-induced Toxicity in Rats}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {1032-1041}, type = {Original Article}, chapter = {1032}, abstract = {

Background: Artemisia absinthium L. is known for its antimalarial activity however, hepatoprotective activity of aqueous extracts has also been reported but, nephroprotective activity not yet evaluated. Objective: To evaluate the hepatoprotective and nephroprotective activities of A. absinthium against diclofenac-induced toxicity on rats. Materials and Methods: Three different doses of methanol and ethyl acetate extract of A. absinthium (50, 100 and 200 mg/kg/day) were evaluated and compared with silymarin 100 mg/kg. Rats received these doses for 5 days and on the 3rd and 4th day diclofenac (50 mg/kg i.p.) was administered 1 h after treatment. Animals were sacrificed 48 h after the last injection of diclofenac. Biochemical blood parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea and creatinine, and histopathologic changes of liver and kidney were studied and evaluated. Results: A. absinthium reduced the elevated blood levels of ALT, AST, ALP, urea and creatinine with the methanol extract to 200 mg/kg/day being more effective. The histopathologic evaluation suggested that A. absinthium decreased hepatic and renal necrosis induced by diclofenac. Conclusions: Hepatoprotective and nephroprotective activities of methanol and ethyl acetate extract of A. absinthium were demonstrated, being methanol extract to 200 mg/kg/day the most effective. This provides scientific support for the use of medicinal plants such as A. absinthium in the treatment of liver and kidney disorders.

}, keywords = {Artemisia absinthium, Biochemical parameters, Diclofenac, Hepatoprotective, Histopathology, Nephroprotective}, doi = {10.5530/pj.2020.12.146}, author = {Sag{\'a}stegui-Guarniz William Antonio and Silva-Correa Carmen R and Villarreal-La Torre V{\'\i}ctor E and Cruzado-Razco Jos{\'e} L and Calder{\'o}n-Pe{\~n}a Abhel A and Aspajo-Villalaz Cinthya L and Gamarra-S{\'a}nchez C{\'e}sar D and Ruiz-Reyes Segundo G and Ch{\'a}vez-Flores Juana E} }