@article {1629, title = {Anti-Cancer Potential of Nggorang Leaves Extract (Salvia Occidentalis SW.) as a Protein P53 Supressor in T47D Cells}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {1036-1045}, type = {Research Article}, chapter = {1036}, abstract = {

Breast cancer is one of the most common types of cancer in women. The high incidence of breast cancer has led to the development of anticancer drugs that are more selective against cancer cells without damaging normal tissues. One of the alternatives in cancer treatment by looking for natural sources that can be developed, Nggorang leaves (Salvia occidentalis Sw.). This plant is found in Tenda Village, Langke Rembong District, Manggarai Regency, NTT Province, when the leaves are harvested for one year and are used as medicine. As a preventive, this leaf has been used for generations as an anticancer (7 leaves boiled with 200 ml of water to 100 ml and then drunk), for wounded breast cancer (crushed leaves and attached to the wound); stamina enhancer, cough, influenza, hemorrhoids, diarrhea, nosebleeds (Primary data, 2014). This study aims to prove the potential of EDG (Nggorang Leaves Extract) as an antiproliferative against Hela cancer cells and protein P53 suppressor. The method used is the Quasy experiment, because this study uses laboratory tests in sample testing. The results of the cytotoxic test of Nggorang Leaves Extract have the potential to be anti-proliferative against cancer cells T47D IC50 at 201 ppm and Nggorang Leaves Extract (EDG) has the potential to increase p53 gene suppression in T47D cancer cells by 94.13\% at a concentration of 50 ppm.

}, keywords = {Anticancer, Nggorang Leaves Extract (Salvia occidentalis Sw), Protein P53, T47D}, doi = {10.5530/pj.2021.13.134}, author = {Sisilia Teresia Rosmala Dewi and M Sabir and Sesilia Rante Pakadang and Sainal Edi Kamal and Santi Sinala} } @article {1633, title = {MIC and MKC Analysis of Herbal Medicine in Indonesia Against Mycobacterium tuberculosis}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1058-1064}, type = {Original Article}, chapter = {1058}, abstract = {

Data shows that the success of the Directly Observed Treatment Shortcourse program(DOTS) in South Sulawesi Province was 74.8\%. Causes of failure include standard drug side effects, length of treatment period and Mycobacterium tuberculosis (M.tb) bacterial resistance. The development of new drugs today in addition to synthetic chemical drugs are also natural materials that have the potential as antituberculosis with various mechanisms. The aim of the research is to prove the potential of plants used by the community as tuberculosis drugs empirically based on phytochemical screening extracts, M.tb sensitivity to extracts and determine the MIC (Minimum Inhibitory Concentration) and MKC (Minimum Killing Concentration) values of M.tb. Selection of plant test materials based on survey results and Riskesdas data in 2015. Testing the potential of plant extracts based on the sensitivity of M.tb to the test material in vitro with an incubation period of 7 weeks. Showed 25 plants that have been used empirically as tuberculosis drugs proved to be potential antibacterial M.tb. Phytochemical screening produces flavonoids and tannins in all extracts. Some extracts contain alkaloids, saponins and steroids. Potential tests show that the extract concentration that is effectively used as a tuberculosis drug is: Meniran leaves and miana 100 ppm. Banana peel and basil leaves 125 ppm. 150 ppm bangle rhizome. Turmeric rhizome 175 ppm. Roselle flowers, soursop leaves and lime 200 ppm. Sandalwood, bitter melon leaves and binahong 225 ppm, Curcuma rhizome, kencur, turmeric and onion tubers, gotu kola leaves, sea lava and papaya 275 ppm. Ginger rhizome, brotowali stem, noni leaf, cloves and mangosteen peel \> 275 ppm. 90\% garlic bulb extract.

}, keywords = {Antituberculosis, MIC, MKC, Plants, Potential}, doi = {10.5530/pj.2021.13.137}, author = {Sesilia Rante Pakadang and Maria Hilaria and Sisilia Teresia Rosmala Dewi and Santi Sinala and Jumain} } @article {1250, title = {The Ability Free Radical Binding of Dengen{\textquoteright}s Stem Bark Extract (Dillenia serrata) From Luwu District Indonesia}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {September 2020}, pages = {1340-1345}, type = {Research Article}, chapter = {1340}, abstract = {

Degenerative diseases such as cancer, heart disease is one of the diseases caused by free radicals. Dengen (Dillenia serrata) is one of Indonesia{\textquoteright}s endemic local plants that has the potential to bind free radicals. So far, only limited to the use of fruit and consumed directly. This study aims to determine the ability of dengen stem bark extract to bind to free radicals expressed in IC50. In the initial research, the total content of polyphenols in dengen stem bark extract was 444.8 mg GAE / g or 44.48\%. Dengen stem bark is extracted by maceration using 70\% ethanol solvent. Antioxidant activity was calculated based on IC50 (Inhibition Concentration) values using the DPPH method, and measured at a wavelength of 516 nm. Ethanol extract of dengen bark is made in 5 concentration series, namely 10 ppm, 20 ppm, 30 ppm, 40 ppm and 50 ppm. Ethanol extract of dengen bark has a very active antioxidant activity with an IC50 value of 48.33 ppm. Whereas for comparison vitamin C has an IC50 value of 15.448 ppm. From the results, it can be concluded that the ethanol extract of dengen bark has the ability to bind free radicals with IC50 48.33 ppm

}, keywords = {Dengen, Ethanol Bark Extract, Free Radicals, IC50}, doi = {10.5530/pj.2020.12.184}, author = {Santi Sinala and Ismail Ibrahim and Alfrida Monica Salasa} }