@article {98, title = {Bio-Flavonoids and Garcinoic Acid from Garcinia kola Heckel Seeds with Promising Antioxidant Potentials}, journal = {Pharmacognosy Journal}, volume = {8}, year = {2016}, month = {09/2015}, pages = {56-58}, type = {Original Article}, chapter = {56}, abstract = {

Objective: The research was carried out to investigate the anti-inflammatory effect of ethanol extract, fraction (kolaviron) and compounds (garcinoic acid, GB1 and GB2) of Garcinia kola seeds. Materials and Method: To evaluate the acute anti-inflammatory effect of extract, fraction and compounds of G. kola carrageenan-induced edema model in wistar albino rats was used. Results: Kolaviron (50 mg/kg), garcinoic acid (50 mg/kg) and the crude extract (50 mg/kg) caused 100, 83 and 74\% inhibition of carrageenan-induced paw edema respectively at 6 h post administration. Indomethacin (10 mg/ kg), the reference drug induced 100\% inhibition of carrageenan-induced paw oedema. While GB1 (50 mg/kg) and GB2 (50 mg/kg) was prominent at 4, 5 and 6 h post administration. Conclusion: Results showed that the extract possessed anti-inflammatory activity, which have justified their use in Nigeria traditional medicine to treat inflammation.

}, keywords = {Anti-inflammatory, Carrageenan, Garcinia kola, Paw edema, Wistar rats.}, doi = {10.5530/pj.2016.1.12}, author = {Tchimene Kenne Michel and Anaga Arua Ottoh and Ugwoke Christopher Emeka Chukwunonye and Ezugwu Christopher Obodoike and Okunji Christopher and Iwu Maurice Mmaduakolam} }