@article {2102, title = {Comparison of Antibacterial and Antioxidant Activities of Ethanolic Extracts of Four Plant Species Selected from South of Saudi Arabia}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {August 2023}, pages = {691-696}, type = {Research Article}, chapter = {691}, abstract = {

One of the most ancient human medical techniques is the use of plants to treat, prevent, and cure diseases. These plants can manufacture a wide variety of natural chemicals. The present study aimed to evaluate the antibacterial activity and antioxidant capacity of ethanolic extract of four plant species (Zizyphus lotus, Lavandula dentata, Ruta graveolens, and Dodonaea viscosa). Using disc diffusion and serial dilution procedures, the antibacterial abilities of these EtPEs were evaluated. The antioxidant properties were evaluated by the FRAP method and the Folin-Ciocalteu technique was used to measure the total phenolic content. Different plant extracts showed different inhibitory effects on the tested bacteria in a dose-dependent manner. Among the tested plant extracts, D. viscose exhibited the highest antibacterial activity against P. vulgaris and S. aureus, with a minimum inhibitory concentration (MIC) value of 0.5 mg/ml. On the other hand, R. graveolens displayed the highest quantity of phenolic compounds and demonstrated the highest antioxidant activity. Notably, there was a positive correlation observed between the antioxidant activity of the plant extracts and their total phenolic content. In conclusion, the findings of this study suggest that the tested plant extracts hold potential as promising sources of natural antibacterial and antioxidant agents.

}, keywords = {Antibacterial, Antioxidants, Extraction, Medicinal Plants., Total Phenols}, doi = {10.5530/pj.2023.15.138}, author = {Ali Abdallah Alqudah and Bilal Al Hawamdeh and Dahfer Ali and Ibrahim Alfarrayeh and Bilal Algataitat and Omar Khaled Al-Mobideen and Mohammad Alhawatema} } @article {1875, title = {Effect of Crataegus aronia on the Biochemical Parameters in Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {October 2022}, pages = {587-595}, type = {Research Article}, chapter = {587}, abstract = {

Crataegus aronia is widely known for its antioxidant, anti-inflammatory, and hypolipidemic properties, and it has traditionally been used to treat cardiovascular disorders. This study aimed to evaluate the impact of Crataegus aronia extract on the liver enzyme markers, blood glucose levels, lipid profiles, and kidney function biomarkers as well as hematological parameters in induced diabetic rats. Male Wistar rats were divided into seven groups: normal Control; Diabetic; and Diabetic animals treated with two doses of Crataegus aronia extract (5 and 10mg/kg) (DM + extract), Control treated with the extract ( 5 and 10mg/ kg) and induced diabetic treated with insulin. Streptozotocin (STZ)-induced diabetic rats (50 mg/kg, ip)and normal were orally administrated with Crataegus aronia extract once a day for 4 weeks. At the end of the experiment, the biochemical and hematological parameters were measured in all groups. Also, the phytochemicals and antioxidant activity of the Crataegus aronia extract were evaluated. According to findings, the total phenols, total flavonoid, and flavonol contents were 538.3 mg Galic acid equivalent /g extract, 149.3 mg Rutin equivalent / g extract, and 79.3 mg Rutin equivalent / g extract), respectively. The antioxidant activity according to 2,2-diphenyl-2-picrylhydrazyl (DPPH) IC50 and ferric reducing antioxidant power (FRAP) assays were 28.02 μg/ml and in the range of 0.273 {\textendash} 0.960 μmol Fe+2/g dw, respectively. Crataegus aronia extract significantly (p \<0.05) affects red blood cells, hemoglobin, hematocrit, white blood cells, lymphocytes, and platelets values. Also, Crataegus aronia had a significant (P \< 0.05) effect on serum biochemical parameters, including glucose, total proteins, albumins, triglycerides, creatinine, bilirubin, and serum aspartate aminotransferase (AST). However, Crataegus aronia treatment had no significant effects (p \< 0.05) on serum alanine aminotransferase, alkaline phosphatase, and cholesterol levels. Crataegus aronia exerts antioxidant activity and significantly improves the biochemical and hematological biomarkers in induced diabetic rats.

}, keywords = {Antioxidant, Biochemical parameters, Crataegus aronia, Diabetes mellitus, Insulin}, doi = {10.5530/pj.2022.14.140}, author = {Omar Khaled Al-Mobideen and Ali Abdallah Alqudah and Ahmed Al-Mustafa and Fuad Alhawarat and Hussam Mizher} } @article {1390, title = {Antibacterial and Antioxidant Activities of Ethanol Extracts of Some Plants Selected from South Jordan}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {528-534}, type = {Research Article}, chapter = {528}, abstract = {

Three Jordanian medicinal plants; Peganum harmala (P. harmala), Geropogon hybridus (G. hybridus), and Salvia officinalis (S. officinalis) were selected from Al-karak region in order to investigate their antibacterial and antioxidant activities. The crude extract yield of all used plants were varied from 10.6\% in Salvia officinalis and 15.6\% in P. harmala, to 18 \% in G. hybridus. The antibacterial activity of these plants was carried out on four bacterial strain (S. aureus, E.coli, E. aerogenes and B. subtilis). These plant ethanol extracts have effects on the gram positive strains and gram negative bacteria except S. officinalis did not show activity against E. Coli. The minimal inhibition concentration (MIC) of P. harmala S. officinalis and G. hybridus (MIC) ranged from 125 μg/ml to 500 μg/ml. The ethanol crude extract of G. hybridus gave 10 fractions using TLC method, fraction 1,3 and 10 exhibited antibacterial activity against all bacterial strains. Their total phenolic contents were evaluated; the highest total phenol content was observed in G. hybridus with 410 mgGAE/g plant extract followed by P. harmala and S. officinalis with 305 and 203.7 mg/g plant extract, respectively. The antioxidant activity was estimated by using DPPH method. The highest antioxidant activity was obtained with G. hybridus extract and found to be 0.89 mg Trolox/g plant extract. The lowest antioxidant activity was obtained with S. officinalis which was 0.53 mg Trolox/g plant extract. The lowest IC50 (highest antioxidant activity) was observed in G. hybridus with 0.83 mg/ml. Intermediate effect observed in P. harmala with IC50 1.1 mg/ml. The lowest antioxidant activity was obtained in S. officinalis with IC50 1.38 mg/ml.

}, keywords = {Antibacterial, Antioxidant, Ethanol extracts, Peganum harmala}, doi = {10.5530/pj.2021.13.66}, author = {Waleed Khaled Al ani and Ali Abdallah Alqudah and Khaled. A. Tarawneh} }