@article {2041, title = {Description of Ciplukan Toxicity (Physalis angulata L.)}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {June 2023}, pages = {357-367}, type = {Research Article}, chapter = {357}, abstract = {

Introduction: Ciplukan (Physalis angulata L.) is a plant used by Indonesian people as traditional medicine. Drug sanitization needs to be carried out to guarantee the use and availability of scientifically safe traditional medicines. This study aims to provide information and enrich knowledge about the safety of consuming ciplukan roots and stems. Methods: This study used 8 male mice as test animals, divided randomly into 4 treatment groups, namely mice treated with a dose of 0.56 mg/20 g body weight; mice treated with a dose of 5.6 mg/20 g body weight; mice treated with 56 mg/20 g body weight; and mice treated with 560 mg/20 g body weight. Treatment was given once and then observed for 24 hours to observe the number of deaths of the test animals. Then follow-up observations were carried out in 3 days on individuals who were still alive. Results: Within 24 hours all individuals at the treatment dose of 0.56 mg/20 g body weight survived, whereas all individuals at the treatment dose of 5.6; 56; and 560 mg/20 g body weight died. The observations on individuals treated at a dose of 0.56 mg/20 g body weight showed that the animals were in good condition, with sleeping and eating activities, moving a lot, having clean and nice fur, and not showing toxic symptoms such as disturbances in physical activity, impaired balance, and refusal to eat. Conclusions: The administration of the test extract below is less or equal to 0.56 mg/20 g body weight is relatively safe.

}, keywords = {Acute toxicity, Ciplukan, Condition, Dosage, Traditional medicine.}, doi = {10.5530/pj.2023.15.85}, author = {Ruqiah Ganda Putri Panjaitan and Titin and Yohanes Gatot Sutapa Yuliana} } @article {1827, title = {Description of Acute Toxicity of Ketepeng Root Extract (Senna alata (L.) Roxb.)}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {August 2022}, pages = {393-401}, type = {Research Article}, chapter = {393}, abstract = {

Introduction: People in Indonesia, especially in the West Kalimantan region often use the root of ketepeng as a medicine to treat jaundice, but they lack knowledge regarding the appropriate dosage. Therefore, this study aims to determine the acute toxicity of ketepeng root extract. Methods: The sample population consists of 8 male mice, which were randomly divided into 4 treatment groups, namely P1, P2, P3, and P4 with dosages of 0.56 mg, 5.6 mg, 56 mg, and 560 mg/20 g body weight, respectively. The extract was administered once, after which the samples were observed for 24 hours to record the number of deaths. Follow-up observations were then carried out for 3 days on the mice that survived the test. Results: The results showed that within 24 hours of administration, the samples in P1 were alive, while all animals in the other groups died. Furthermore, the follow-up observations on animals that survived showed that they were in good condition with no toxic symptoms, such as balance disorders, refusal to eat, and lack of physical activity. Conclusion: Based on the results, the administration of 0.56 mg/20 g body weight of the extract was relatively safe, while higher doses can cause death. However, further testing must be carried out to complete the toxicity information as well as to determine the exact dosage range to avoid mortality during the treatment.

}, keywords = {Acute toxicity, Fabaceae, Roots of Senna alata (L.) Roxb}, doi = {10.5530/pj.2022.14.113}, author = {Ruqiah Ganda Putri Panjaitan and Titin and Yohanes Gatot Sutapa Yuliana} } @article {1613, title = {Ethno-Medicinal Plants Used for Medication of Jaundice by The Chinese, Dayak, and Malays Ethnic in West Kalimantan, Indonesia}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {916-923}, type = {Research Article}, chapter = {916}, abstract = {

Knowledge in the utilization of plants as medicine is local wisdom passed down from generation to generation. This study aims to make an inventory of plants that is efficacious in overcoming jaundice which is used by ethnic Chinese, Dayak, and Malay people in West Kalimantan. This research applies ethnobotany and medical ethnobiology approaches by using observation techniques, semi-structural interviews, also recording and documenting plant species to overcome jaundice. There were 23 types of medicinal plants used by ethnic Chinese, Dayak, and Malay people to overcome jaundice. The 23 types of plants obtained were tebu hitam (Saccharum officinarum L.), pisang mas (Musa paradisiaca L.), kacang hijau (Vigna radiata L.), bawang dayak (Eleutherine palmifolia (L.) Merr.), temulawak (Curcuma xanthorrhiza Roxb.), lipan-lipan (Chrysopogon aciculatus (Retz.) Trin), ciplukan (Physalis angulata L.), cha chen chou/ sawi (Plantago mayor L.), inai (Lawsonia inermis L), kunyit (Curcuma domestica Val.), kelapa gading (Cocos eburen Durch), belimbing manis (Averrhoa Carambola L.), ilalang (Imperata cylindrica (L) Beauv.), sia li chi o kin/putri malu kuning (Neptunia oleracea Lour.), ketepeng (Senna alata (L.) Roxb.), putri malu bunga ungu (Mimosa pudica L.), stet ma thio kin/bunga kancing (Urena lobata L.), tebu karak (Saccharum officinarum L.), kumis kucing (Orthosiphon aristatus (Blume) Miq.), empedu tanah/sambiloto (Andrographis paniculata (Burm.f.) Wall. Ex Nees), pegage/pegagan (Centella asiatica L. Urban), kai kut chou/tulang ayam (Clinacanthus nutans (Burm.f.) Lindau), and bambu kuning (Bambusa vulgaris Schrad.).

}, keywords = {Jaundice, Local Wisdom, Medicinal plants}, doi = {10.5530/pj.2021.13.118}, author = {Ruqiah Ganda Putri Panjaitan and Titin and Yohanes Gatot Sutapa Yuliana} }