@article {1842, title = {Amino Acid and Proximate Analysis of Type-1 Collagen from Sea Cucumber and Tilapia-Skin and its Potential Application as Artificial Tendon}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {August 2022}, pages = {358-361}, type = {Original Article }, chapter = {358}, abstract = {

Tendon injury is a medical indication that requires surgical therapy and prolonged recovery. Collagen plays a crucial role in the wound healing process. Collagen maintains homeostasis, interacts with platelets, and enhances cellular components. Most living organisms consist of collagen components as fibrillar proteins. In this study, the potential properties of type-1 collagen from sea cucumber and Tilapia-skin were evaluated depend on proximate analysis, amino acid composition, and moisture-absorption ability. The result showed that Tilapia-skin has a higher protein and fat composition compared to the sea cucumber. In contrast, moisture, ash, and yield composition showed higher for sea cucumber compared to Tilapiaskin. Meanwhile, based on amino acid analysis was revealed that proline, alanine, methionine, isoleucine, leucine, phenylalanine, and lysine were lower on sea cucumber compared to Tilapia-skin. In conclusion, both type-1 collagen material from sea cucumber and Tilapia-skin might be developed as a biomaterial for tendon injury. It is crucial that further studies be carried out to emphasize the potential of biodegradable and bio-replaceable materials using the in vivo model.

}, keywords = {collagen, Key words: Artificial tendon, Marine biodiversity, Sea cucumber, Tilapia-skin}, doi = {10.5530/pj.2022.14.107}, author = {Arifia Safira and Cinta Atsa Mahesa Rani and Roro Ayu Puspitasari and Anindyta Kirana Putri Ayuningtyas and Yayang Amru Mahendra and Agus Purnomo and Faisal Fikri and Shekhar Chhetri and Muhammad Thohawi Elziyad Purnama} } @article {1787, title = {A Review of an Important Plants: Annona squamosa Leaf}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {April 2022}, pages = {456-463}, type = {Review Article}, chapter = {456}, abstract = {

Plants have been utilized extensively in traditional medicine by a range of nations since ancient times, and more research into their safety, efficacy, and quality value is needed. One of the plants that have been widely used by society in traditional medicine is Annona squamosa L. A. squamosa is commonly cultivated in tropical and subtropical regions. Based on previous research, all parts of A. squamosa including bark, leaf, and roots have proven biological activities such as antioxidant, antifungal, and anticancer, especially on the leaves. Indian people have long history used young leaves of A. squamosa for antidiabetic, besides in South China, they use seeds to decrease the cancer effect in the human body. The pharmacological activities of A. squamosa leaves are antimicrobial, antifungal, anti-inflammatory, anticancer, antiulcer, antidiabetic, antidiarrheals, antiplatelet, antioxidant, and hepatoprotective, neuroprotective, and cytoprotective. Phytochemicals in A. squamosa leaves include coumarins, tannins, cardiac glycosides, flavonoids, carbohydrates, and saponins. Meanwhile based on nutritional analysis shows that the A. squamosa leaves are water, protein, lipids, Fiber Ash and Calcium.

}, keywords = {Annona squamosa, Medicine, Pharmacology, Phytochemistry, Traditional medicinal plant}, doi = {10.5530/pj.2022.14.58}, author = {Arifia Safira and Prasita Widayani and Dhiya An-Najaaty and Cinta Atsa Mahesa Rani and Mela Septiani and Yan Arengga Syah Putra and Tridiganita Intan Solikhah and Aswin Rafif Khairullah and Hartanto Mulyo Raharjo} }