@article {1980,
	title = {Inflammatory Thyroid Changes Following Serotonin Receptor Blocking in Experimental Rats},
	journal = {Pharmacognosy Journal},
	volume = {15},
	year = {2023},
	month = {March 2023},
	pages = {189-193},
	type = {Research Article},
	chapter = {189},
	abstract = {<p class="rtejustify">According to studies, a pathophysiological feature of schizophrenia may be a dysregulation of the inflammatory immune response. Conversely, antipsychotic medications have been found to have an immunosuppressive effect in patients with schizophrenia; however, this has not been consistently observed in different studies. The purpose of the following study is to compare the effects of risperidone with aripiprazole on thyroid function as it relates to inflammatory markers (CRP). This study was based on a randomized controlled trial. A total of thirty rats were recruited for the experiment and were kept in the artificial, and optimal environment. The rats were divided into three groups; each group has an equal number of rats which was 10 rats each. The first group was the control group which received the placebo, in the second group, there were 10 rats too, which was known as the risperidone group. Each rat received 20mg/kg/day through I/V. The third group is known as the aripiprazole group which received the drug from the intravenous route, 10mg/kg//day. In the results, the summarized values represented that all the mean values before and after the treatment remained less than 3.0. From the results and other evidence, it can be said that although the subjects who receive the following results do not require regular or frequent monitoring of thyroid hormones in long-term use and in the use of the drug in higher concentration there must be a check as long term use is associated with hyperthyroidism.</p>
},
	keywords = {Aripiprazole, FT3, FT4, Risperidone., Thyroid, Thyroxine, Tri-iodothyronine},
	doi = {10.5530/pj.2023.15.28},
	author = {Muthear N Dawood and Karam A. Aldabbagh and Zahraa Alsarraf}
}
@article {1870,
	title = {Artificial Sweeteners Perturbed Liver Enzymes in Rat Model},
	journal = {Pharmacognosy Journal},
	volume = {14},
	year = {2022},
	month = {October 2022},
	pages = {553-557},
	type = {Research Article},
	chapter = {553},
	abstract = {<p class="rtejustify">In the recent time there has been an increased demand of low-fat or low calorie diet universally. In the mean while the availability of low calorie products has also increased like sugar free drinks, beverages, biscuits, jams and jellies. On contrary to this, some studies suggest that the prolong use of non-nutritive sweeteners alters the homeostasis of glucose and insulin. It results in fluctuation of glucose level in blood and increase in bodyweight. This study intends to evaluate the effect of non-nutritive sweeteners on the liver function test and record the alteration in the levels of ALP, AST and ALT. Seventy rats were divided into seven equal groups, controlled group received distilled water and the rest six were given NNS Sucrose, Stevia, Sucralose, Saccharine Aspartame and Acesulfame-k, respectively. On the evaluation of Alanine aminotransferase ALT, saccharine and aspartame markedly increased the level of ALT from 40U/L to 80 U/L. Both of these NNS have shown the most raised level of Alanine aminotransferase. This represents the stress on the liver associated with the use of NNS and suggests the use to be controlled in humans.</p>
},
	keywords = {Albumin, Artificial Sweeteners, Bilirubin, Liver Enzyme},
	doi = {10.5530/pj.2022.14.135},
	author = {Muthear N Dawood and Shaymaa AH. Jassim and Maab Azmi Fadel and Imad A. Thanoon}
}
