@article {2282, title = {In-silico Prediction of Epigallocatechin-3-Gallate (EGCG) vs Retinol in Photoaging Therapy}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {April 2024}, pages = {366-371}, type = {Original Article}, chapter = {366}, abstract = {

Background: Skin aging is a cumulative damage that occurs due to complex biological processes from genetic and environmental factors that are evident in individual{\textquoteright}s appearance. Clinically photoaging causes wrinkling, telangiectasia, dryness, pigment changes and loss of elasticity. As the predominant element found in green tea, epigallocatechin-3-gallate (EGCG) exhibits an active physiological function observed in both human and animal skin. Exposure to the two components of solar UV radiation that reach the earth surface, UVA (320{\textendash}400nm) and UVB (290{\textendash}320nm), leads to protein oxidative damage, lipid oxidation, DNA chain damage, and depletion of antioxidant enzymes. Since 1984, all-trans retinol has been incorporated into over-the-counter (OTC) cosmetic products, yet its potential in treating photoaging continues to be investigated. Methods: Search Profile EGCG, Retinol, Hyaluronan, and then Bioactive Prediction with SAR. Predicted EGCG targets were analyzed using Comparative Toxicogenomics Database. Compound Profile Similarity with Tanimoto Similarity. Using AlphaFold model, we obtained three-dimensional configuration of Hyaluronan Synthase 1, as designated target protein in this study, from Uniprot database (https://www. uniprot.org/) with identifier Q92839. Results: Based on SAR analysis to predict potential bioactivity, it shows that EGCG has better potential than retinol as an antioxidant and free radical scavenger. Target prediction with CTD shows that in curated studies the EGCG CTD is able to target COL1A1, HAS1, NFE2L2, and MMP1. Based on tanimono similarity, the similarity between EGCG and Hyaluron is higher than Hyaluron and Retinol. Conclusions: Docking analysis shows that it is predicted that EGCG is better at interacting with HAS1 and MMP1.

}, keywords = {Docking, EGCG, HAS, MMP1}, doi = {10.5530/pj.2024.16.56}, author = {Riyana Noor Oktaviyanti and Cita Rosita Sigit Prakoeswa and Esti Hendradi, and Anang Endaryanto} } @article {1906, title = {Risk Factors of Acute and Chronic Erythema Nodosum Leprosum in Dr. Soetomo General Academic Hospital Surabaya}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {December 2022}, pages = {766-770}, type = {Original Article}, chapter = {766}, abstract = {

Background: Leprosy is a chronic granulomatous infection and is one of the neglected diseases caused by Mycobacterium leprae. ENL is a complex syndrome, that caused inflammation of the skin, nerves, and other organs due to an inflammatory immune response to Mycobacterium leprae antigens. Acute ENL was defined as the first episode of ENL with a duration of less than 24 weeks. Chronic ENL was defined as ENL that persisted for more than 24 weeks. These types of ENL can have different risk factors and require different therapeutic interventions. Purpose: The onset of ENL is acute, but may progress to a chronic or recurrent phase and require long-term therapy. Early detection of leprosy is very important, because the infection is curable and prompt treatment can reduce nerve damage and associated stigma. Chronic ENL patients require prolonged high doses of corticosteroids to control inflammation in ENL and cause severe complications and side effects associated with morbidity and mortality. Methods: This retrospective study was conducted using a non-probability sampling technique consecutively using a casecontrol formula in leprosy patients with ENL in the Leprosy Division of the Outpatient Dermatology and Venereology Unit RSUD Dr. Soetomo Surabaya for the period 2015 {\textendash} 2020, using secondary data in the form of medical record data. Result: The results of this study obtained leprosy patients with ENL as many as 234 patients, 56 patients with acute ENL and 89 patients with chronic ENL. 45 patients with acute ENL and 45 patients with chronic ENL were obtained from the case-control minimal sample size formula. Conclusion: The results of the bivariate analysis test showed that there was a relationship between risk factors for coinfection and steroid therapy with the type of ENL. The presence of coinfection and steroid therapy showed that patients tend to be chronic ENL, conversely, in the absence of coinfection and without steroid therapy, patients tend to be acute ENL. The multivariate logistic regression analysis test showed a significant association between risk factors for ENL onset before MDT and the presence of coinfection with chronic ENL, whereas ENL onset after MDT and absence of coinfection were associated with acute ENL.

}, keywords = {Acute ENL, Chronic ENL, ENL, Leprosy, Neglected disease., Risk factors}, doi = {10.5530/pj.2022.14.165}, author = {Ditya Indrawati and Linda Astari and Afif Nurul Hidayati and Sawitri, Damayanti and Budi Utomo and Bagus Haryo Kusumaputra and Medhi Denisa Alinda and Cita Rosita Sigit Prakoeswa and M. Yulianto Listiawan} }