@article {1910, title = {Nano Transdermal Delivery Potential of Fucoidan from Sargassum sp. (Brown Algae) as Chemoprevention Agent for Breast Cancer Treatment}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {December 2022}, pages = {789-795}, type = {Research Article }, chapter = {789}, abstract = {

Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy{\textquoteright}s side effects. Fucoidan is an anticancer bioactive compound derived from Sargassum sp. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from Sargassum sp. against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and in silico study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from Sargassum sp. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services.

}, keywords = {Anticancer, Breast cancer, Fucoidan, Nano transdermal, Sargassum sp. .}, doi = {10.5530/pj.2022.14.169}, author = {Syeftyan Muhammad Ali Hamami and Michelle Fai and Ahmad Fariduddin Aththar and M Nizam Zulfi Zakaria and Viol Dhea Kharisma and Ahmad Affan Ali Murtadlo and Muhammad Badrut Tamam and Vikash Jakhmola and Muhammad Hermawan Widyananda and Dora Dayu Rahma Turista and Maksim Rebezov and Nikolai Maksimiuk and Nataliya Kulmakova and Evgeniya Latynina and ANM Ansori and Rahadian Zainul and Riso Sari Mandeli and Devi Purnamasari and Oski Illiandri and Khoirun Nisyak and Ernarisa Fitri} }