@article {1965, title = {The Relationship Between Enteral and Parenteral Nutrition on Body Weight, Incidence of NEC, Sepsis and Length of Care for Preterm Infant in Dr. Soetomo General Hospital Surabaya}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {March 2023}, pages = {86-89}, type = {Original Article }, chapter = {86}, abstract = {

The incidence of preterm birth in Indonesia still accounts for the highest mortality rate. Failure to provide adequate nutrition will have an impact on growth failure, risk of infection and longer duration of care for preterm infant. This study aims to analyzing the relationship between enteral and parenteral nutrition on body weight, the incidence of NEC, the incidence of sepsis and the length of care at Dr. Soetomo Hospital Surabaya. A total 106 subjects were enrolled, 78 infants were LBW, 19 infants were VLBW. Gestational age between 32-\<37 weeks as many as 96 subjects. 68 infants were female. A total of 49 patients (46.2\%) received parenteral nutrition. There is a relationship between enteral nutrition and the incidence of sepsis (p= 0.03), parenteral nutrition and body weight (p= 0.005), parenteral nutrition and the incidence of sepsis (p= 0.001), and parenteral nutrition and the length of care for preterm infants (p= 0.001). There is a relationship between enteral nutrition with the incidence of sepsis and parenteral nutrition with body weight, incidence of sepsis and length of care in preterm infants.

}, keywords = {Enteral, Hospitalization., Neonatal sepsis, Parenteral nutrition, Preterm infant}, doi = {10.5530/pj.2023.15.12}, author = {Aldila Pratiwi and Martono Tri Utomo and Risa Etika and Kartika Darma Handayani and Dina Angelika} } @article {1950, title = {The Role of Breast Milk on Reducing the Risk of Neonatal Sepsis in Preterm and Low Birth Weight Infants: A Systematic Review and Meta-Analysis}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {January 2023}, pages = {1067-1074}, type = {Review Article}, chapter = {1067}, abstract = {

Background: High mortality and morbidity rates are associated with neonatal sepsis in preterm and low birth weight infants. Aside from controlling the nosocomial infection, intervention for reducing the risk of sepsis is demanded. The best nutrition for preterm infants is breast milk. Bioactive compounds found in it, such as antibacterial, antiviral, and anti-inflammatory activities not only for immunity against the infection but also for growth, and development. Objective: To investigate the effect of breast milk against the risk of neonatal sepsis in preterm and low birth weight infants. Methods: We conducted an electronic search through several databases including PubMed, Web of Science, Science Direct, and Scopus. We performed an analysis on nutritional feeding and volume of breast milk and late-onset sepsis from ten potential observational studies. Results: Breast milk significantly reduced the risk of sepsis in preterm and low birth weight infants (pooled RR 0.70; 95 \% CI 0.55 - 0.88, p = 0.002). In addition, when we performed subgroup analysis, we found that breast milk volume \> 50ml/kgbw/day also reduce the risk of sepsis with pooled RR 0.61(95\% CI 0.46-0.8, p=0.0004). Conclusion: Low birth weight and preterm infants had a lower risk of neonatal sepsis when they got breastmilk. To preserve the supply of breastmilk, health professionals should support and encourage mothers who were breastfeeding.

}, keywords = {Breast milk, Low birth weight, Neonatal sepsis, Preterm infant}, doi = {10.5530/pj.2022.14.211}, author = {Tita Natalia Manurung and Citrawati Dyah Kencono Wungu and Martono Tri Utomo} }