@article {1999, title = {The Effect of Moringa Leaf Extract Intervention Since Preconception Period on the Prevention of Oxidative Stress in Pregnant Women and Adverse Pregnancy Outcomes}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {310-314}, type = {Original Article }, chapter = {310}, abstract = {

Background: Oxidative stress occurs due to an imbalance of oxidants and anti-oxidants and is often associated with poor pregnancy outcomes. Therefore, additional supplementation is needed since the preconception period to prevent oxidative stress and poor pregnancy outcomes. This study aims to examine the effect of supplementing Moringa leaf extract on the prevention of oxidative stress in pregnant women and poor pregnancy outcomes. Methods: This study is an observational study with a prospective cohort study design. The research subjects were third trimester pregnant women consisting of 2 groups, namely the control group who only received Iron-Folic Acid (IFA) supplements (n = 30) and the group that received moringa leaf extract and IFA supplements (n = 26). Then an examination of Malondialdehyde (MDA) levels as a biomarker of oxidative stress was carried out using the ELISA (enzyme-link immune sorbent) method, followed by pregnancy outcomes including birth weight and birth length. Data were analyzed by unpaired t test. Results: The results showed that there were no significant differences in the levels of MDA, birth weight and birth length in the two groups with a p value \> 0.05. Nevertheless, MDA level in IFA group was 49.25 nmol/ml higher than Moringa + IFA group which was 47.58 nmol/ml. Likewise, the average of birth weight and birth length in Moringa group were 3042.3 grams and 48.62 cm higher than IFA group which were 2993.7 grams and 48.23 cm. Malondialdehyde levels were also higher in women who had babies with birth weight \< 2500 grams was 49.48 nmol/ml and birth length \< 48 cm was 49.13 nmol/l compared to birth weight >= 2500 grams was 48.50 nmol/ml and birth length >= 48 cm was 48.62 nmol/ml but there was no significant difference in the two groups (p\>0.05). Conclusion: Oxidative stress in pregnant women tends to be associated with poor pregnancy outcomes. Moringa leaf extract supplementation since preconception can prevent increased oxidative stress and improve pregnancy outcomes.

}, keywords = {Malondialdehyde, Moringa oleifera, Oxidative stress, Pregnancy outcomes.}, doi = {10.5530/pj.2023.15.45}, author = {Rahma and Veni Hadju and A. Arsunan Arsin and Aminuddin Syam and Anwar Mallongi and Abd. Farid Lewa and Haerani Harun and Miranti} } @article {1995, title = {The Effect of Preconcenption Moringa Leaf Extract Supplementation on Cotinine Serum Levels in Pregnant Women Exposed to Tobacco Smoke}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {290-293}, type = {Original Article }, chapter = {290}, abstract = {

Background: Moringa oleifera is known for its nutrition content, antioxidant and medical benefit. Tobacco smoke contains various toxic substance and can affect the pregnancy. To reduce the tobacco smoke effect on pregnancy outcome good nutrition is needed. Objective: This study aims to assess the effect of Moringa leaf extract on serum cotinine levels in pregnant women exposed to second-hand tobacco smoke. Method: This is an observational study with a prospective cohort study design the study population was pregnant women which were divided by 2 groups, first group received IFA supplements only (n = 30) and the second group receive IFA and Moringa leaf extract supplements (n = 26). The tobacco smoke exposure data collected with questionnaire, and cotinine serum by blood sample. The tobacco smoke exposure and cotinine serum levels were compered between the two groups. Results: The tobacco smoke exposures at home were higher in MO+IFA group pregnant women then the IFA group pregnant women (p\<0,05). The cotinine serum levels in both groups were found not significantly different (p=0,535). These results indicate that pregnant woman with high exposure of tobacco smoke who MO receive have similar cotinine serum levels with the pregnant woman with lower exposure of tobacco smoke. Conclusion: Moringa leaf extract supplementation to pregnant women with high tobacco smoke exposure has serum cotinine levels similar to pregnant women with lower exposure to tobacco smoke.

}, keywords = {Cotinine, Moringa oleifera., Preconception, Tobacco smoke}, doi = {10.5530/pj.2023.15.41}, author = {Haerani Harun and Anwar Daud and Ridwan Amiruddin and M Sabir and Veni Hadju and Anwar Mallongi and Rahma and Miranti and Tamrin Talebe and M. Faris} }