@article {2551, title = {Hydrolyzed Collagen Tonic Drink Prevents Worsening of Skin Parameters and Improves Photoaging Classification in Healthy Thai Women: A Randomized Controlled Trial}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {September 2025}, pages = {644-652}, type = {Original Article}, chapter = {644}, abstract = {

Background: Skin aging represents a significant public health burden globally, with Southeast Asian populations experiencing accelerated photoaging due to intensive environmental ultraviolet exposure. Aim: To evaluate the preventive efficacy of hydrolyzed collagen tonic drink on skin aging parameters in healthy Thai women. Methods: A double-blind, randomized controlled trial was conducted with 135 Thai women aged 40-60 years. Participants were randomized to receive either hydrolyzed fish collagen peptides with supportive nutrients (n=67) or active fruit juice control (n=68) daily for 12 weeks. Primary outcomes included skin microtopography parameters measured by Visioscan, skin elasticity assessed by Cutometer, and clinical photoaging classification using Glogau scale. Secondary outcomes examined molecular biomarker changes in procollagen Type I synthesis. Results: The collagen group demonstrated significantly attenuated skin surface deterioration compared to placebo. The Wrinkles parameter showed significant betweengroup differences at week 8 (-100.43 units, p=0.001). Smoothness parameter exhibited protective effects with significant between-group differences at week 8 (-80.08 units, p=0.002). Gross elasticity improved significantly within the collagen group at week 12 (p=0.033). Procollagen Type I synthesis demonstrated superior maintenance in the collagen group versus placebo (between-group percent change difference, p=0.002). Both groups achieved comparable Glogau classification improvements (23.9\% versus 20.6\%). Conclusion: Daily hydrolyzed collagen supplementation with supportive nutrients effectively prevented skin surface parameter deterioration in Thai women, demonstrating meaningful preservation of skin integrity through medium effect sizes for key parameters. These findings support nutritional approaches as complementary strategies for photoaging management in high ultraviolet-exposure populations

}, keywords = {Dermal aging, Hydrolyzed collagen, photoaging, Skin elasticity, Wrinkle}, doi = {10.5530/pj.2025.17.81}, author = {Uratchat Vichaidit and Chuntida Kamalashiran and Kammal Kumar Pawa and Pratya Phetkate} } @article {2295, title = {Efficacy and Safety of Traditional Transdermal Patch (Ya-Pok- Dud-Pid) in Primary Knee Osteoarthritis Patients: A Randomized Controlled Trial}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {June 2024}, pages = {570-575}, type = {Original Article}, chapter = {570}, abstract = {

Background: Patients with Knee Osteoarthritis (KOA) have a progressive decline in their social and physical abilities, which affects their quality of life. The Thai Traditional Transdermal Patch (Ya-Pok-Dud- Pid; YP) has been widely used for the treatment of KOA. Objective: To determine the clinical efficacy and safety of YP in comparison with diclofenac gel (DG) for the treatment of KOA. Methods: 74 primary KOA Patients were enrolled and randomly assigned to YP groups or DG groups. The outcomes were assessed the Visual Analog Scale (VAS), Time Up and Go (TUG), Active Knee Flexion (AKF) and Passive Knee Flexion, chair sit and reach, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results: YP and DG significantly improved VAS, TUG, AKF, PKF, chair sit and reach, and WOMAC (p \< 0.05). Remarkably, YP experienced the same immediate pain relief after day 1 treatment as DG. The VAS scores of the YP group exhibited a significant reduction from 60{\textpm}11.06 to 38.92{\textpm}17.76, while DG decreased VAS score from 61.24{\textpm}17.84 to 39.19{\textpm}20.05 (p \<0.001). However, there was no significant difference between the two treatment groups. For adverse event, skin reaction (rash, itchy, and dry skin) was noted in the YP group because of the participant receiving YP for an extended period. Altogether, YP has a similar effect to diclofenac gel on pain severity and physical function in patients with knee osteoarthritis. Conclusion: YP is recommended as a natural therapeutic agent with efficacy and safety treatment for knee osteoarthritis.

}, keywords = {Diclofenac, Osteoarthritis of knee, Traditional, Transdermal Patch}, doi = {10.5530/pj.2024.16.89}, author = {Chutharat Saereewat and Kusuma Sriyakul and Parunkul Tungsukruthai and Sunyarn Niempoog and Sucharat Tungsukruthai and Chuntida Kamalashiran} } @article {2235, title = {Safety Assessment of Oral Lysiphyllum strychnifolium Aqueous Extract in Healthy Volunteers}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {February 2024}, pages = {235-240}, type = {Research Article}, chapter = {235}, abstract = {

Background: Lysiphyllum strychnifolium (LS), widely known as Ya nang daeng in Thailand, is a traditional herbal remedy that has long been used to promote health and treat diverse health conditions, especially detoxification, by alleviating the severity of symptoms and lowering the risks associated with toxic exposures. Although it is extensively used in Thailand, human safety studies have been lacking. Thus, this study aimed to examine the safety of using LS capsules in healthy participants through a Phase I clinical trial. Objective: This study aimed to investigate the safety of aqueous extract of LS in twenty-four healthy Thai participants. Method: The participants were received 1,000 mg of LS aqueous extract each morning before their meals for seven days. All participants were examined safety assessment including history taking, physical examination, and laboratory tests at day 0, 8 and 14 (follow-up). Results: The findings showed that there were no significant side effects or abnormalities found during the history taking, physical examination, or laboratory evaluation. Particularly, when compared to baseline, participants who received LS experienced statistically significant reductions in blood sugar, triglyceride, LDL cholesterol, and creatinine (P \< 0.05), but still within normal ranges. Conclusions: Dietary supplementation with 1,000 mg of LS aqueous extract per day may have a beneficial effect on blood sugar and cholesterol management while remaining safe for healthy people.

}, keywords = {Clinical study, Healthy volunteers, Lysiphyllum strychnifolium, Safety, Yanang Daeng}, doi = {10.5530/pj.2024.16.34}, author = {Piracha Jumpa-ngern and Parunkul Tungsukruthai and Chuntida Kamalashiran and Somboon Kietinun and Kesara Na- Bangchang and Kusuma Sriyakul} }