@article {2378, title = {Influence of Chamomile Leaves extract in Different Doses on Renal Functions and Diabetic indices in Streptozotocin {\textendash} Induced Diabetic Rat}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {October 2024}, pages = {1029-1035}, type = {Original Article}, chapter = {1029}, abstract = {

Background: The prevalence of diabetes among Egyptians is rising. Therefore, there is always a demand for innovative natural medicines. Medicinal plants have long been a significant source in search of novel, effective alternatives for human therapy. Chamomile is one of the most widely used medicinal plants, which may help hyperglycemic patients by lowering blood sugar levels. Objectives: To determine how chamomile extract affects the kidneys when albino male rats with chronic diabetes are induced by streptozotocin (STZ). Methods: The study was conducted in the Al-Azhar Faculty of Medicine (Assiut) pharmacology department animal laboratory. For this investigation, a local strain of fifty adult male albino rats was used as the animal model and weighed 120 to 150 g. In this study, rats were divided into five groups, body weight, and systolic blood pressure was measured, and blood samples were collected for measuring blood glucose and insulin level, HbA1c, Na, K, and renal function tests, and histopathological examination was done. Results: After the study, mean glucose levels, HbA1c, urea, creatinine, K, and systolic blood pressure were significantly decreased in group IV \& group V compared to group III. In contrast, body weight serum insulin level and Na increased dramatically in group IV \& group V compared to group III. Conclusion: The serum levels of urea and creatinine in diabetic patients may be positively affected by chamomile. Additionally, short-term chamomile uses benefits diabetic individuals by decreasing loss of body weight, lowering HbA1c, and increasing insulin levels.

}, keywords = {Chamomile leaves, Diabetes mellitus, Streptozotocin}, doi = {10.5530/pj.2024.16.166}, author = {Mohamed Zaeim Hafez Ahmed and Muhammad Abdelbaeth Hassan Elfiky and Elsayed Elagamy Elsayed Mohamed and Ramadan Hassan Ibrahim Thabet and Ahmed Mohamed Gad Allah and Ahmed Abdrabo Elshenawy Elsisi and Ahmed Abdel Nasser Ahmed Mohamed and Tarek Shikhon and Mostafa Abo-akrab and Sayed A.M.Mahmoud and Mohamed AbdelAziz Doma and Wael Ahmed Mahmoud Khattab and Khaled Saleh Ali Elhamaky and Mohamed El- Salamoni and Fatma Mahmoud Abdelraheem and Mahmoud Ahmad Mohamed Azab and Mahmoud Ahmad Mohamed Azab6 and Mohamed E EL-Refaey and Ahmed A. Abd El-Rhman and Ahmed F. Abdel Ghany and Ghada Adel Hegazy} }