@article {2512, title = {Formulation Strategy and Excipient Selection for Tribulus terrestris L. Tablets: A Quality-Based Approach}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {June 2025}, pages = {370-377}, type = {Research Article}, chapter = {370}, abstract = {

Background: To develop and evaluate a tablet formulation containing standardized dry extract of Tribulus terrestris L.{\textemdash}a plant traditionally used in Mongolian medicine{\textemdash}by focusing on excipient optimization and pharmaceutical quality assessment. Methods: Tablets were manufactured using the wet granulation method, incorporating an extract standardized to 54.45\% dioscin. Various excipient ratios were investigated to determine the optimal formulation. Dioscin content was quantified using UV-visible spectrophotometry. Results: The optimized formulation comprised 25\% dry extract, 34\% lactose, 34\% microcrystalline cellulose, 6\% PVPP, 0.5\% magnesium stearate, 0.5\% talc, and 4.5\% HPMC. The tablets demonstrated acceptable pharmaceutical characteristics, including an average weight of 0.113 {\textpm} 0.001 g, hardness of 0.83 {\textpm} 0.23 MPa, friability of 98.17 {\textpm} 0.65\%, and disintegration time of 7.30 minutes. The dioscin content was 13.50 {\textpm} 0.50 mg/g, with an assay recovery of 95.51\%. Dissolution exceeded 83\% in both media within 45 minutes. The similarity factor (f$_{2}$) confirmed equivalent dissolution profiles. Conclusion: The developed T. terrestris tablet formulation met pharmacopoeial standards and exhibited consistent physical, chemical, and biopharmaceutical performance, supporting its potential as a standardized herbal medicinal product for clinical and commercial application.

}, keywords = {Tribulus Terrestre{\textquoteright}s L.; tablet; excipients; saponins; spectrophotometer}, doi = {10.5530/pj.2025.17.46}, author = {Baigalmaa Dovchinsuren and Wang Qin Hu and Jambaninj Dambiinyam and Yerkyebulan Mukhtar and Davaadagva Damdinjav and Enkhjargal Dorjbal} } @article {2394, title = {Technological Study on The Synthesis of Silver Nanoparticles Using Plant Extracts Via Biosynthesis Methods}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {October 2024}, pages = {1124-1130}, type = {Research Article}, abstract = {

Introduction: Silver nanoparticles are better than other metal nanoparticles in terms of antimicrobial activity and stability. Recently, the biosynthesis method has been widely used, known for being ecofriendly and having lower toxicity compared to other methods of obtaining metal nanoparticles. This method is characterized by the use of active pharmaceutical ingredients contained in medicinal plants as stabilizers or bio reducers to produce silver nanoparticles. Methods: In this study, we synthesized silver nanoparticles using extracts from the upper parts of Cacalia hastata L., Thymus gobicus Czern., and Glycyrrhiza uralensis Fisch., which were collected from various provinces from Mongolia. These medicinal plants are used as bio reducing agents. We determined the most sensitive light absorption of each sample with purified silver nanoparticles using a UV-M51 ultraviolet spectrophotometer. Sizes and distributions were analyzed through Nanophox Particle Size Analysis, while morphological structure was examined using energy dispersive X-ray spectroscopy (EDX). The formations of nanoparticles were determined with instruments such as X-Ray Diffraction (XRD). Results: The appropriate formation times for nanoparticles were 24 minutes with Cacalia hastata L. extract and 16 minutes with Thymus gobicus Czern. extract. XRD analysis revealed characteristic peaks at 38.15{\textdegree}, 44.3{\textdegree}, and 64.55{\textdegree}, indicating the formation of a crystalline structure and confirming the presence of silver nanoparticles. Conclusion: Furthermore, these nanoparticles exhibited antibacterial activity against both S. aureus and E. coli.

}, keywords = {Antimicrobial, Bio reducing, Eco-friendly, Mongolian plants}, doi = {10.5530/pj.2024.16.183}, author = {Bilguun Enkhbat and Buyankhishig Dorjsuren and Tserennadmid Erdenebaatar and Myagmarsuren Badamtsetseg and Zolbayar Baasanjav and Enkhtuul Bayarsaikhan and Shinezaya Dashbaljir and Khatanbold Otgonbayar and Buyanjargal Erdenebat and Jambaninj Dambiinyam and Otgonsuren Daramzav} }