@article {2497, title = {Acute and Subchronic Toxicity Study of Sampilnorov Wurile}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {April 2025}, pages = {203-210}, type = {Original Article}, chapter = {203}, abstract = {

Introduction: Sampilnorov Wurile (SW) is a traditional medicinal preparation containing 29 plant-, mineral-, and animal-derived components. It is used for cerebrovascular ischemia, retinal disorders, cardiovascular diseases, and neurological conditions. This study aimed to evaluate the acute and subchronic toxicities of SW. Methods: Acute toxicity was assessed in C57BL/6 mice based on OECD-423 guidelines, with oral doses ranging from 500 to 6,000 mg/kg body weight. Subchronic toxicity was evaluated in Wistar rats following OECD-407 guidelines, with daily oral doses of 300 and 600 mg/kg of SW daily for 4 weeks. Clinical signs, mortality, body weight, and physical condition were monitored. Hematological, biochemical, and histopathological analyses were conducted on day 29. Results: No mortality or significant clinical signs of toxicity were observed at doses up to 6,000 mg/kg, suggesting an oral median lethal dose exceeding this level. Subchronic toxicity assessment revealed no clinical signs of toxicity or mortality. SW at 300 and 600 mg/kg had no significant effects on serum biochemical parameters or vital organ histology compared to controls. Conclusion: SW exhibited no acute toxicity at doses up to 6,000 mg/kg and showed no adverse effects in a 28-d subchronic toxicity study. These findings support its safety at tested doses.

}, keywords = {Acute and subchronic toxicity; biochemistry; blood test; histopathological analysis; Sampilnorov Wurile}, doi = {10.5530/pj.2025.17.25}, author = {Li ChangSheng and Chimgee Tserendash and Maral-Erdene Gerelt-Od and Batdavaa Batbayar and Uyangamaa Altankhuyag and Mend-Amar Batbaatar and Narankhajid Myadagsuren and Davaadagva Damdinjav and Enkhmaa Gonchig and Yeruult Chultemsuren} } @article {2473, title = {Medicinal Application of the Iceland Poppy (Papaver nudicaule L.) in Traditional Mongolian Medicine}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {January 2025}, pages = {71-76}, type = {Research Article}, chapter = {71}, abstract = {

In recent years, there has been a considerable focus on the utilization of natural medicinal substances, including plant-based medicines and formulations. While traditional medicine has been utilizing various medicinal plants to treat a wide range of diseases, there are still many medicinal plants and substances that have not been thoroughly studied at the scientific level. One such plant is the Iceland poppy (Papaver nudicaule L.) from the Papaveraceae family. Globally, the Papaveraceae family comprises 44 genera and 760 species of which 32 species, representing 7 genera, are identified within Mongolia. The Iceland poppy (Papaver nudicaule L.) is extensively distributed throughout Mongolia, with all parts of the plant, including its fruit and flowers. In addition, it has been traditionally employed in Mongolian medicine to treat a variety of ailments. However, systematic research on the practical applications and studies of the status of the local Iceland poppy in both modern and traditional Mongolian medicine remains poorly reported. Therefore, we aim to conduct a comprehensive and comparative study of the Iceland poppy (Papaver nudicaule L.) and its application in the Traditional Mongolian medicinal literature and internationally published studies. Materials and Methods: In this study, data was collected from a comprehensive review of the international and Traditional Mongolian medicine literature to understand the medicinal application of the Iceland poppy. Additionally, current study results were analyzed to assess its practical applications and efficacy in modern medicinal contexts. Results: "In a variant of Mongolian medicinal prescriptions, the Iceland poppy (Papaver nudicaule L.) is combined with the herb {\textquotedblleft}Govo jad-5{\textquotedblright} Mongolian traditional prescription for treating surgical wounds, torn blood vessels, and both old and new wounds. Furthermore, the book {\textquoteright}Methods and Prescriptions for Using Medicinal Plants in Traditional Mongolian Medicine reports that Iceland poppy is part of a mixture of four types of poppies used to treat conditions such as diarrhea, intestinal inflammation, and dysentery, by boiling and administering the concoction. A study by Otgonpurev Sukhbaatar et al., (2018) determined that the optimal conditions for callus and suspension biomass production of Papaver nudicaule L. are 1 mg/L naphthalene acetic acid and 0.5 mg/L benzyl adenine in MS media. Additionally, Gerelt-Od Yadamsuren et al., reported that the alkaloids 8,14-dihydroamurin, 8,14-dihydroflavinantin, and flavinantin from Papaver nudicaule L. exhibit significant antiviral activity against human rhinovirus-14. Conclusion: Iceland poppy (Papaver nudicaule L.) has been used in traditional Mongolian medical practice for a long time. it has been historically widely used in Mongolian traditional medicine to treat wounds under the name of {\textquotedblleft}wound healer{\textquotedblright}. As reported by the scientific literature, the primary uses of these plants include inhibiting acetylcholinesterase enzyme, anti-cancer effects, as well as antioxidant and anti-inflammatory properties. Furthermore, regarding its chemical composition, researchers have conducted studies that confirm the presence of alkaloids in this plant, specifically isoquinoline alkaloids. These compounds are known for their diverse biological activities and potential therapeutic effects, which may contribute to the plant{\textquoteright}s traditional medicinal uses. In summary, the Iceland poppy (Papaver nudicaule L.) has been utilized in traditional medicine for treating a variety of illnesses; however, it suggests that more comprehensive research is necessary to scientifically substantiate these applications.

}, keywords = {Alkaloids, Medicinal plant, Nudicaulins, Papaver nudicaule L., Protopine, Traditional Mongolian medicine}, doi = {10.5530/pj.2025.17.9}, author = {Enkhtuul Bayarsaikhan and Turtushikh Damba and Buyanjargal Erdenebat and Norovnyam Ryenchinbyambaa and Otgonsuren Daramzav and Khuvitavilan Battulga and Munkhzul Boldbaatar and Myagmarsuren Badamtsetseg and Enkhjargal Dorjval and Davaadagva Damdinjav and Otgonbaatar Urjin and Maria Halabalaki and Wirginia Kukula-Koch and Daariimaa Khurelbat} }