@article {1713, title = {Antidiabetic Activity of the Leaf Extract of Eurycoma Longifolia Jack. in Streptozotocin-Nicotinamide Induced Diabetic Model}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {December 2021}, pages = {1582-1588}, type = {Original Article}, chapter = {1582}, abstract = {

Background: One of the medication attempts in diabetes mellitus is by utilising plants that are potent as an antioxidant. Eurycoma longifolia Jack. known as {\textquotedblleft}Longjack{\textquotedblright} in English, is a medicinal plant and reportedly effective as an antioxidant. Objectives: This study was aimed to examine the antidiabetic effectiveness of ethanol extract of longjack leaf in diabetes mellitus rats. Methods: This study used the total of 24 male white rats which were grouped into four. The normal and the negative control groups were administrated with CMC-Na 0.5\% dose 2 ml/200 g body weight; one group was administrated with ethanol extract of longjack leaf dose 176.4 mg/200 g body weight; and the positive control group was administrated with glibenclamide dose 0.09 mg/200 g body weight. Before the extract administration, all of the experimental animals were prior induced into diabetic condition with streptozotocin-nicotinamide. Results: The levels of blood glucose and malondialdehyde in rats after the 14-day extract treatments were 78.73 mg/dl and 1.13 nmol/ml, respectively in the normal control group; 285.84 mg/dl and 10.03 nmol/ml were in the negative control group; 156.77 mg/dl and 3.86 nmol/ml in the group with the administration of ethanol extract of longjack leaf; and 148.63 mg/dl dan 3.64 nmol/ml in the group of glibenclamide administration (p\<0.05). The reduction of blood glucose and malondialdehyde levels in the groups of ethanol extract administration of longjack leaf dose 176.4 mg/200 g body weight was similar to the glibenclamide administration dose 0.09 mg/200 g body weight. Conclusion: The ethanol extract of longjack leaf was effective as an antidiabetic.

}, keywords = {Blood glucose level, Diabetes mellitus, Eurycoma longifolia Jack. leaf.}, doi = {10.5530/pj.2021.13.203}, author = {Ruqiah Ganda Putri Panjaitan and Agus Astuti} } @article {1237, title = {Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous alcoholic Extract on Blood Glucose Level of Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {September 2020}, pages = {1218-1222}, type = {Original Article}, chapter = {1218}, abstract = {

Introduction: Diabetes mellitus is a metabolic disorder, which affects many people throughout the world. The inefficacy and multiple side effects of most synthetic anti-diabetic drugs are reported by various studies. Thus, many researchers are focused on the use of medicinal plants as safe and potent anti-hyperglycemic drugs. The aim of this study is the evaluation of the effect of Afghan senjed (Elaeagnus Angustifolia L.) leaves aqueous alcoholic extract on blood glucose level of diabetic rats. Methods: Rats were divided into 6 groups: normal, diabetic, metformin and Elaeagnus Angustifolia leaves extract (EALE) groups, which received 200, 400 and 800 mg/kg doses of extract for 15 days. Diabetes was induced by single dose intraperitoneal administration of streptozotocin (STZ). During treatment, the effect of single and repeated oral administration of EALE on blood glucose level of diabetic rats was evaluated. On last day, the effect of EALE on oral glucose tolerance test (OGTT) was also assessed. Results: All doses of EALE showed significant reduction in blood glucose level, an improvement of glucose tolerance and enhancement in body weight. Conclusion: EALE possessed an antihyperglycemic property in diabetic rats.

}, keywords = {Blood glucose level, Diabetic rats, Elaeagnus Angustifolia leaves, Glucose tolerance, Streptozotocin}, doi = {10.5530/pj.2020.12.170}, author = {Hamida Sadat and Kawsar Alami and Sayed Yousof Mousavi} } @article {322, title = {Fasting Blood Glucose Levels and Hematological Values in Normal and Streptozotocin-Induced Diabetic Rats of Mimosa pudica L. Extracts}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {April 2017}, pages = {315-322}, type = {Original Article}, chapter = {315}, abstract = {

Context:M. pudica is a common plant found in moist waste ground, lawns, open plantations and weedy thickets. Aims: The fasting blood glucose levels (FBG) and hematological values of M. pudica aqueous(MPA) and hydro-ethanolic (MPHE) extract were evaluated in normal and streptozotocin (STZ)-induced diabetic rats. Materials and Methods: MPA and MPHE 125, 250 and 500 mg/kg body weight (b.w.) were administered orally and daily to the rats for 8 weeks. The FBG were determined weekly. Red blood cells (RBC), hemoglobin (HM. pudicab), hematocrit (Hct), platelet, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cells (WBC), lymphocytes, monocytes, neutrophils and eosinophil were evaluated. Results: MPA and MPHE had no effect on blood glucose levels in normal rats. All doses of all extracts showed significantly (p\<0.05) decreasing FBG in diabetic rats. Especially MPA at the dose of 250 mg/kg b.w. showed more potent significantly (p\<0.05) decreasing blood glucose levels than anti-diabetic drug glibenclamide at the end of experiment. All extracts had no effect on RBC, Hb, Hct, platelet, MCH, MCHC, lymphocytes, monocytes neutrophils and eosinophils. Surprisingly, the extracts were decreased WBC and MCV in diabetic rats. In addition, all of the extracts did not produce the alteration of blood cells structure in all rats. Conclusion: This study indicated that the extracts were hypoglycemic effect and improve hematological values in diabetes which confirms the traditional use of the plant.

}, keywords = {Blood glucose level, Hematological values, Mimosa pudica, Red blood cell, White blood cell}, doi = {10.5530/pj.2017.3.54}, url = {/files/PJ-9-3/10.5530pj.2017.3.54}, author = {Ampa Konsue and Chayan Picheansoonthon and Chusri Talubmook} }