@article {2565, title = {Ultrasonographic and Biochemical Evaluation of the Hepatoprotective Effect of Cinnamomum burmannii Bark Extract in Carbon Tetrachloride{\textendash}Induced Liver Injury}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {December 2025}, pages = {751-759}, type = {Original Article}, chapter = {751}, abstract = {

This study aimed to evaluate the hepatoprotective activity of ethanolic extract of cinnamon (Cinnamomum burmannii) in male Wistar rats induced with carbon tetrachloride (CCl$_{4}$). Cinnamon extract is known to contain bioactive compounds such as flavonoids and polyphenols, which play significant roles in antioxidant and anti-inflammatory mechanisms. Phytochemical analysis revealed that the extract contained total phenolic content of 71.55 mg GAE/g and flavonoid content of 0.41 mg QE/g, with a potent antioxidant activity indicated by an IC$_{5}$$_{0}$ value of 18.19 ppm. Administration of the extract for 28 days at a dose of 300 mg/kg body weight resulted in a significant reduction (P\<0.05) in pro-inflammatory cytokines TNF-α, IL-6, and CRP levels compared to the negative control group. The 300 mg/kg dose showed the highest efficacy, with TNF-α levels approaching those of the normal group. Furthermore, liver function parameters improved, as evidenced by significant reductions in SGOT and SGPT enzyme levels, an increase in serum albumin (2.96 {\textpm} 0.52 g/dL), and a decrease in serum bilirubin to 0.102 {\textpm} 0.040 mg/dL. Ultrasonographic examination showed improved liver parenchymal homogeneity and a reduction in the number of nodules. Histopathological findings revealed a decrease in liver tissue damage score from moderate to mild. These findings suggest that Cinnamomum burmannii extract has potential hepatoprotective effects through antiinflammatory, antioxidant, and hepatocellular recovery mechanisms. Therefore, this extract holds promise as a phytopharmaceutical candidate for complementary therapy in liver function disorders; however, further studies are required to isolate the active compounds and evaluate long-term toxicity.

}, keywords = {Anti-inflammatory, Antioxidant, Cinnamon, Cytokine, Hepatoprotective, Histopathology}, doi = {10.5530/pj.2025.17.94}, author = {Inda Kania Meilani and Ermi Girsang and Yolanda Eliza Putri Lubis} } @article {337, title = {Antibacterial Activity of Endophytic Fungi Isolated from the Bark of Cinnamomum mercadoi}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {April 2017 }, pages = {405-409}, type = {Original Article}, chapter = {405}, abstract = {

Introduction: Cinnamomum mercadoi is a medicinal tree endemic to the Philippines. Cinnamomum species have been extensively studied for their endophytic fungi with pharmacological importance. This study aims to isolate and evaluate the antibacterial activity of endophytic fungi associated with the bark of C. mercadoi. Materials and Methods: Endophytic fungi were isolated from surface sterilized bark samples aseptically. The pure isolates were identified through their morphological characteristics. Agar plug diffusion assay was employed in the primary screening of their antibacterial activity against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Four active endophytes were fermented and extracted with ethyl acetate (EtOAc). The antibacterial activity of the EtOAc extracts was screened using the disk diffusion assay. The minimum inhibitory activity (MIC) was evaluated using the microdilution method. Results: Twelve (12) endophytes were isolated from the bark of C. mercadoi. All endophytes exhibited antibacterial activity on at least one of the test pathogens. However, only two of the four endophytes subjected to the secondary screening showed wide-spectrum activity and inhibited the growth of all test bacteria. Fusarium sp. 2 was identified to have the most promising activity with MIC values ranging from 2.1 - 4.2 mg/mL. Conclusion: C. mercadoi harbors endophytes, particularly Fusarium sp. 2, which possess antibacterial activity and thus a potential source of antibacterial compounds.

}, keywords = {Cinnamon, Escherichia, Fusarium}, doi = {10.5530/pj.2017.3.69}, url = {/files/PJ-9-3/10.5530pj.2017.3.69}, author = {Jia P. Marcellano and Alyssa S. Collanto and Rolly G. Fuentes} }