@article {355, title = {Pharmacognostic Studies and HPLC Analysis of Roots of Helicteres isora (L.)}, journal = {Pharmacognosy Journal,}, volume = {9}, year = {2017}, month = {May 2017}, pages = {523-527}, type = {Original Article}, chapter = {523}, abstract = {

Background: The juice of roots of Helicteres isora Linn. has been widely used as an antidiabetic in traditional medicine. Objective: The present study deals with pharmacognostical studies and determination of oleanolic acid from the roots of H. isora by new HPLC method. Materials and methods: Detailed study of morphological, microscopical characteristics, physicochemical parameters and phytochemical screening of roots were carried out. The sapogenins were isolated from the roots of H. isora. RP-HPLC method was developed and validated for estimation of oleanolic acid from the sapogenins of roots of H. isora. Results: Detailed quality control parameters of roots of H. isora were reported. Total content of oleanolic acid was 0.075\%w/w from roots of H. isora determined by HPLC. Conclusion: The present study is useful for accurate identification and authentication of roots of H. isora. The HPLC method for determination of oleanolic acid from the roots of H. isora is efficient, precise, reliable and sensitive and can be adopted for routine analysis.

}, keywords = {Helicteres isora, HPLC, Oleanolic acid, Sapogenins}, doi = {10.5530/pj.2017.4.84}, url = {/files/PJ-9-4/10.5530pj.2017.4.84}, author = {Pinal A. Harde and Mamta B. Shah} } @article {1529, title = {Protective role of Helicteres isora plant extract on plasma and tissue glycoprotein components in streptozotocin induced hyperglycemic rats}, journal = {Pharmacognosy Journal}, volume = {6}, year = {2014}, month = {26th May 2014}, pages = {86-91}, type = {Research Article}, abstract = {

The present investigation was carried out to evaluate the protective role of Helicteres isora plant extract on glycoprotein metabolism in streptozotocin (STZ) induced type 2 diabetic rats. Helicteres isora plant extract was administered orally (200 mg/kg body weight) for 40 days to normal and diabetic rats. The effects of Helicteres isora plant extract on plasma and tissue glycoproteins (hexose, hexosamine, sialic acid and fucose) were determined. The levels of plasma glycoproteins containing hexose, hexosamine, sialic acid and fucose were significantly increased in diabetic rats when compared with normal control rats. There was a significant decrease in the level of sialic acid and elevated levels of hexose, hexosamine and fucose in the liver and kidney of STZ induced diabetic rats. On oral administration of Helicteres isora plant extract to diabetic rats showed decreased levels of plasma glycoproteins. The level of tissue sialic acid was increased whereas the levels of tissue hexose, hexosamine and fucose were reversed to near normal. The present study indicates that the Helicteres isora plant extract possesses a significant protective effect on glycoprotein metabolism in addition to its anti-diabetic effect.

Key words:Helicteres isora, Diabetes, Plasma Glycoproteins, Streptozotocin.

}, keywords = {Diabetes, Helicteres isora, Plasma Glycoproteins, Streptozotocin}, author = {C.Elanchezhiyan and K.Kumaravel and Ahmad bhat and S.Sethupathy} }