@article {2295, title = {Efficacy and Safety of Traditional Transdermal Patch (Ya-Pok- Dud-Pid) in Primary Knee Osteoarthritis Patients: A Randomized Controlled Trial}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {June 2024}, pages = {570-575}, type = {Original Article}, chapter = {570}, abstract = {

Background: Patients with Knee Osteoarthritis (KOA) have a progressive decline in their social and physical abilities, which affects their quality of life. The Thai Traditional Transdermal Patch (Ya-Pok-Dud- Pid; YP) has been widely used for the treatment of KOA. Objective: To determine the clinical efficacy and safety of YP in comparison with diclofenac gel (DG) for the treatment of KOA. Methods: 74 primary KOA Patients were enrolled and randomly assigned to YP groups or DG groups. The outcomes were assessed the Visual Analog Scale (VAS), Time Up and Go (TUG), Active Knee Flexion (AKF) and Passive Knee Flexion, chair sit and reach, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results: YP and DG significantly improved VAS, TUG, AKF, PKF, chair sit and reach, and WOMAC (p \< 0.05). Remarkably, YP experienced the same immediate pain relief after day 1 treatment as DG. The VAS scores of the YP group exhibited a significant reduction from 60{\textpm}11.06 to 38.92{\textpm}17.76, while DG decreased VAS score from 61.24{\textpm}17.84 to 39.19{\textpm}20.05 (p \<0.001). However, there was no significant difference between the two treatment groups. For adverse event, skin reaction (rash, itchy, and dry skin) was noted in the YP group because of the participant receiving YP for an extended period. Altogether, YP has a similar effect to diclofenac gel on pain severity and physical function in patients with knee osteoarthritis. Conclusion: YP is recommended as a natural therapeutic agent with efficacy and safety treatment for knee osteoarthritis.

}, keywords = {Diclofenac, Osteoarthritis of knee, Traditional, Transdermal Patch}, doi = {10.5530/pj.2024.16.89}, author = {Chutharat Saereewat and Kusuma Sriyakul and Parunkul Tungsukruthai and Sunyarn Niempoog and Sucharat Tungsukruthai and Chuntida Kamalashiran} } @article {2296, title = {Evaluation of Potential Toxicity Associated with Antidiabetic Herbs in Saudi Arabia}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {June 2024}, pages = {576-581}, type = {Original Article}, chapter = {576}, abstract = {

Introduction: Diabetes mellitus is a serious, long-lasting disease that is characterized by high blood sugar levels, leading to more severe complications involving other organ systems of the body. Diabetes is becoming more common worldwide. Managing diabetes can be complicated, but many people, especially in Saudi Arabia, often use traditional herbal medicines to treat the condition. Our study concentrates on assessing the safety of commonly used antidiabetic herbs in Saudi Arabia by examining their potential toxicity. Method: Using keywords and their variations, we conducted a systematic search of the PubMed and Google Scholar databases to find studies on treatments based on antidiabetic herbs and their toxic effects from 2014 to 2024. Result: Our study revealed that the use of medicinal plants for treating and managing diabetes along with its complications is becoming popular around the globe. These medicinal plants are also being used as primary sources of developing modern pharmaceutical antidiabetic drugs. Phytotherapy is safe to treat diabetes as herbal bioactive components act through many biological pathways. They may inhibit α-glucosidase enzyme, enhance GLUT-4 translocation, and also improve lipid profile. Conclusion: The use of natural plants having medicinal properties is popular for the treatment of diabetes. Claims of their usefulness by traditional healers are being supported by scientific evidence also. To determine the right dosage of these medicinal herbs, cytotoxicity tests or short-term experiments are done to establish doses of plants used in vitro and in vivo. Toxicity concerns are a primary reason why healthcare professionals hesitate to incorporate herbal products into the healthcare system. That{\textquoteright}s why it is necessary to screen such plants for their toxicity to differentiate pharmacological efficacy from adverse effects.\ 

}, keywords = {Antidiabetic, Diabetes, Herbal medicines, KSA, Medicinal herbs, Phytotherapy, Plant extracts, Saudi Arabia, Toxicity, Traditional}, doi = {10.5530/pj.2024.16.90}, author = {Inbaraj Susai Domnic and Prasanna Mohanabhaskaran and Imran Zaheer and Semmal Syed Meerasa and Ramaprabha Prabhakar} } @article {404, title = {Contemporary Use of Phytocosmetics in Three Districts from North-Eastern Algeria}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {762-766}, type = {Original Article}, chapter = {762}, abstract = {

Background: In Algeria, the cosmetic market is competitive, with an annual growth of 12\%. Because of the toxicity of synthetics cosmetics, the industry is currently more concentrated on herbal cosmetics. Phytocosmetic is an important aspect of traditional medicine in Algerian culture, whose information is scanty. Objective: The present study has been conducted to assess quantitatively the use of herbs in phytocosmetics application. Method: Data was collected from 300 users via face to face interviews using semi-structured questionnaire in three districts from North-eastern Algeria: Annaba, El Tarf and Skikda. Five parameters were evaluated including the demographic characteristics, the form of cosmetic preparation and, medicinal stories used in cosmetic applications. Results: The soap (67\%) and a fixed oil (56\%) were the preparation forms most used in phytocosmetics applications. Although, five medicinal plants were recorded: Aloe vera (L.) Burm.F., Matricaria recutita L., Lavandula angustifolia Mill., Citrus limon (L.) Osbeck and Ricinus communis L. The highest relative citation frequency (RFC) was attributed to A. vera in the three district Skikda (0.68), Annaba (0.57), and El Tarf (0.43). Eleven traditional recipes have been described. Conclusion: This study is able to record the available information the importance of phytocosmetic in traditional medicine. However, further research should be conducted in Algeria, to explore the toxicity of these products.

}, keywords = {Algeria, Medicine, Phytocosmetic, Scanty., Toxicity, Traditional}, doi = {10.5530/pj.2017.6.120}, url = {http://fulltxt.org/article/173}, author = {Amel Bouzabata} }